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| | 1-tert-butyl azepane-1,4-dicarboxylate 4-ethyl ester Basic information |
| Product Name: | 1-tert-butyl azepane-1,4-dicarboxylate 4-ethyl ester | | Synonyms: | 1H-Azepine-1,4-dicarboxylic acid, hexahydro-, 1-(1,1-diMethylethyl) 4-ethyl ester;1-tert-Butyl 4-ethyl azepane-1,4-dicarboxylate;1-Boc-azepane-4-carboxylic acid ethyl ester;1-tert-butyl azepane-1,4-dicarboxylate 4-ethyl ester;1-O-tert-butyl 4-O-ethyl azepane-1,4-dicarboxylate | | CAS: | 912444-90-7 | | MF: | C14H25NO4 | | MW: | 271.35 | | EINECS: | | | Product Categories: | | | Mol File: | 912444-90-7.mol |  |
| | 1-tert-butyl azepane-1,4-dicarboxylate 4-ethyl ester Chemical Properties |
| Boiling point | 341.6±35.0 °C(Predicted) | | density | 1.057±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -2.04±0.40(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | 1-tert-butyl azepane-1,4-dicarboxylate 4-ethyl ester Usage And Synthesis |
| Synthesis | General procedure for the synthesis of ethyl 1-azepane-N-Boc-4-carboxylate from 1-tert-butyl 4-ethyl 1H-azepine-1,4-dicarboxylate from 2,3,6,7-tetrahydro-1H-azepine-1,4-dicarboxylic acid: 1-tert-butyl 4-ethyl azepine-1,4-dicarboxylate (0.54 g, 2.0 mmol) was dissolved in 20 ml of methanol, 10% Pd/C (50 mg) was added , and the reaction was carried out overnight under hydrogen atmosphere. After completion of the reaction, the solid catalyst was removed by filtration and the filtrate was concentrated. The resulting residue was purified by fast column chromatography (eluent: hexane solution of 20% ethyl acetate) to afford the target product ethyl 1-azepane-N-Boc-4-carboxylate (310 mg, 55% yield). The mass spectrum (DCI/NH3) showed m/z 272 (M+H)+. | | References | [1] Patent: US2006/229289, 2006, A1. Location in patent: Page/Page column 22-23 |
| | 1-tert-butyl azepane-1,4-dicarboxylate 4-ethyl ester Preparation Products And Raw materials |
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