7-Bromo-5H-pyrido[4,3-b]indole

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7-Bromo-5H-pyrido[4,3-b]indole manufacturers
7-Bromo-5H-pyrido[4,3-b]indole Basic information
Synthesis Uses
Product Name:7-Bromo-5H-pyrido[4,3-b]indole
Synonyms:7-Bromo-5H-pyrido[4,3-b]indole 95+%;5H-Pyrido[4,3-b]indole, 7-bromo-;7-BROMO-5H-PYRIDO[4,3-B]INDOLE ISO 9001：2015 REACH;Flortaucipir Impurity 27;7-Bromo-5H-pyrido[4,3-b]indole
CAS:1015460-59-9
MF:C11H7BrN2
MW:247.09
EINECS:
Product Categories:
Mol File:1015460-59-9.mol
7-Bromo-5H-pyrido[4,3-b]indole Structure
7-Bromo-5H-pyrido[4,3-b]indole Chemical Properties
Boiling point 443.6±25.0 °C(Predicted)
density 1.699±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka14.04±0.40(Predicted)
form solid
color Yellow-brown
Safety Information
HS Code 2933998090
MSDS Information
7-Bromo-5H-pyrido[4,3-b]indole Usage And Synthesis
Synthesis

Synthetic route of 7-bromo-5H-pyrido[4,3-B]indole

Step 1: Preparation of 3-(4-bromobenzene)-4-nitropyridine

2.02 g (10.0 mmol) 3-bromo-4-nitropyridine, 2.20 g (11.0 mmol) 4-bromophenylboronic acid, 0.46 g (0.4 mmol) tetrakis(triphenylphosphine)palladium, and 1.33 g (25 mmol) NaCO3 were dissolved in 60 mL of dioxane and 10 mL of water. The mixture was refluxed at 110 °C for 12 h, cooled, poured into 80 mL of water, and then extracted three times with 100 mL of ethyl acetate. The mixture was dried over anhydrous magnesium sulfate.

The solvent was removed under vacuum, and the solid was separated by column chromatography to obtain 2.1 g of yellow solid product (yield: 75%).

Step 2: Preparation of 7-bromo-5H-pyrido[4,3-B]indole

1.68 g of 3-(4-bromobenzene)-4-nitropyridine was dissolved in 60 mL of triethyl phosphite, heated at 110 °C for 3 h under nitrogen protection, cooled, and the triethyl phosphite was removed under reduced pressure. The resulting solid was separated by column chromatography to obtain 1.05 g of brownish-yellow solid product (yield: 71%).

Uses7-Bromo-5H-pyrido[4,3-b]indole is a useful research chemical.
7-Bromo-5H-pyrido[4,3-b]indole Preparation Products And Raw materials
Preparation Products1533432-50-6
Tag:7-Bromo-5H-pyrido[4,3-b]indole(1015460-59-9) Related Product Information
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