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| | 6-Amino-2,4-dimethyl-3-pyridinecarbonitrile Basic information |
| | 6-Amino-2,4-dimethyl-3-pyridinecarbonitrile Chemical Properties |
| Melting point | 230 °C | | Boiling point | 314.5±42.0 °C(Predicted) | | density | 1.14±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 4.30±0.48(Predicted) | | Appearance | Off-white to yellow Solid |
| | 6-Amino-2,4-dimethyl-3-pyridinecarbonitrile Usage And Synthesis |
| Synthesis | To a solution of 5-iodo-4,6-dimethylpyridin-2-amine (10 g, 40.3 mmol, 1.0 eq.) in N,N-dimethylformamide (DMF, 300 mL) was sequentially added zinc cyanide (Zn(CN)2, 14 g, 120.9 mmol, 3.0 eq.) and tetrakis(triphenylphosphine)palladium (Pd(PPh3)4, 4.65 g, 4.03 mmol, 0.1 equiv). The reaction mixture was stirred at 90 °C under nitrogen (N2) protection overnight. After completion of the reaction, extraction was carried out by adding ethyl acetate (EA) and water. The organic layer was separated and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=100/1, v/v) to afford 6-amino-2,4-dimethyl-3-cyanopyridine (5 g, 84% yield) as a yellow solid. | | References | [1] Patent: WO2017/1926, 2017, A2. Location in patent: Paragraph 00123 |
| | 6-Amino-2,4-dimethyl-3-pyridinecarbonitrile Preparation Products And Raw materials |
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