- KN-92
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- $1980.00
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2026-05-11
- CAS:176708-42-2
- Purity:
- Supply Ability: 10g
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| Product Name: | KN92 | | Synonyms: | N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE;KN-92;KN 92;KN92;Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-4-methoxy-;K 92;K92;KN-92 free base | | CAS: | 176708-42-2 | | MF: | C24H25ClN2O3S | | MW: | 456.99 | | EINECS: | | | Product Categories: | | | Mol File: | 176708-42-2.mol |  |
| Boiling point | 602.1±65.0 °C(Predicted) | | density | 1.282±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥ 15.1 mg/mL in DMSO, ≥ 24.2 mg/mL in EtOH with gentle warming | | form | Solid | | pka | 8.49±0.10(Predicted) | | color | White to off-white |
| Uses | KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2]. | | References | [1] Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070. DOI:10.1074/jbc.M202928200
[2] An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448. DOI:10.3748/wjg.v13.i9.1445 |
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