| Company Name: |
SuZhou ShiYa Biopharmaceuticals, Inc.
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86(512)5235 8471 17715136450 |
| Email: |
sales@shiyabiopharm.com |
| Products Intro: |
Product Name:2-(4-BroMo-phenyl)-3-Methyl-butyronitrile
CAS:51632-12-3
Purity:>95% Package:1g;5g Remarks:S1-6547
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| Company Name: |
Zhengzhou AiXi Technology Co., Ltd.
|
| Tel: |
0371-56787280 13137706083 |
| Email: |
m18539565376@163.com |
| Products Intro: |
Product Name:2-(4-BroMo-phenyl)-3-Methyl-butyronitrile
CAS:51632-12-3
Purity:96% Package:100mg-250g
|
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| | 2-(4-BroMo-phenyl)-3-Methyl-butyronitrile Basic information |
| | 2-(4-BroMo-phenyl)-3-Methyl-butyronitrile Chemical Properties |
| Boiling point | 315.1±17.0 °C(Predicted) | | density | 1.305±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature |
| | 2-(4-BroMo-phenyl)-3-Methyl-butyronitrile Usage And Synthesis |
| Synthesis | 2-(4-Bromophenyl)-3-methylbutanenitrile was synthesized as follows: to a solution of 4-bromophenylacetonitrile (20.0 g, 0.102 mol) in DMF (300 mL) was slowly added NaH (60% oil suspension, 4.28 g, 0.107 mol) at 0 °C. After addition, the mixture was continued to be stirred for 15 min, followed by the addition of 2-bromopropane (9.60 mL, 0.107 mol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. Upon completion of the reaction, the mixture was concentrated under vacuum. The residue was extracted by partitioning between dichloromethane (CH2Cl2) and brine. The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum. Finally, the residue was purified by fast column chromatography (silica gel, gradient elution with heptane solution of 0-15% ethyl acetate) to afford the target product 2-(4-bromophenyl)-3-methylbutanenitrile (21.3 g). Mass spectral analysis showed m/z 238.3, 240.2 [M/M+2H]+. | | References | [1] Journal of Medicinal Chemistry, 2015, vol. 58, # 4, p. 1669 - 1690
[2] Patent: WO2012/24150, 2012, A1. Location in patent: Page/Page column 109
[3] Patent: US2013/195879, 2013, A1. Location in patent: Paragraph 0217; 0218
[4] Journal of the American Chemical Society, 2016, vol. 138, # 47, p. 15303 - 15306
[5] Chem.Abstr., 1974, vol. 80, # 120746, |
| | 2-(4-BroMo-phenyl)-3-Methyl-butyronitrile Preparation Products And Raw materials |
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