| Company Name: |
MedChemexpress LLC
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| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:Stavudine (sodium)
CAS:134624-73-0
Purity:>98% Package:750RMB/100mg
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| Company Name: |
LETOPHARM LIMITED
|
| Tel: |
+86-21-5821 5861 |
| Email: |
sales@letopharm.com |
| Products Intro: |
Product Name:Stavudine (sodiuM)
CAS:134624-73-0
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Email: |
eric_feng1954@126.com |
| Products Intro: |
Product Name:Stavudine (sodiuM)
CAS:134624-73-0
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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Stavudine (sodiuM) manufacturers
- Stavudine sodium
-
- $2785.00 / 50mg
-
2026-04-20
- CAS:134624-73-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Stavudine (sodiuM) Basic information |
| | Stavudine (sodiuM) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder |
| | Stavudine (sodiuM) Usage And Synthesis |
| Uses | Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis[1][2][3][4]. | | in vivo | Stavudine (d4T) sodium (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice[5].
| Animal Model: | Male RjOrl Swiss mice weighing 0.028-0.03 kg[1] | | Dosage: | 500 mg/kg | | Administration: | Daily liquid; 2 weeks | | Result: | Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group.
Significantly elevated plasma ALT and LDH levels.
Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels.
Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg. |
| | IC 50 | HIV-1; HIV-2; NLRP3 | | References | [1] Moyle GJ, et al. The role of stavudine in the management of adults with HIV infection. Antivir Ther. 1997;2(4):207-218. PMID:11327440
[2] Riddler SA, et al. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T). Antiviral Res. 1995;27(3):189-203. DOI:10.1016/0166-3542(95)00016-f
[3] La Rosa F, et al. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019;72(2):401-412. DOI:10.3233/JAD-181259
[4] Ferraresi R, et al. Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Lett. 2006;580(28-29):6612-6616. DOI:10.1016/j.febslet.2006.11.016
[5] Anissa Igoudjil, et al. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antivir Ther. 2007;12(3):389-400. PMID:17591029 |
| | Stavudine (sodiuM) Preparation Products And Raw materials |
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