187870-95-7
| 中文名称 | 187870-95-7 |
|---|---|
| 中文同义词 | 盐酸RIMEPORIDE |
| 英文名称 | Rimeporide Hydrochloride |
| 英文同义词 | Rimeporide Hydrochloride;EMD-87580 hydrochloride;Sodium-hydrogen Exchanger,EMD-87580,Rimeporide hydrochloride,Na+/H+ Exchanger (NHE),EMD 87580,EMD87580,Sodium/hydrogen Exchanger,Rimeporide,inhibit,Inhibitor |
| CAS号 | 187870-95-7 |
| 分子式 | C11H16ClN3O5S2 |
| 分子量 | 369.84 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 187870-95-7.mol |
| 结构式 |  |
187870-95-7 性质
| 熔点 | >196oC (dec.) |
|---|---|
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于DMSO（轻微）、甲醇（轻微、加热） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
Rimeporide hydrochloride (EMD-87580 hydrochloride) 是一种有效的选择性 Na+/H+ 交换泵 (NHE-1) 抑制剂。
NHE1
Blocking NHE-1 activity has been shown to decrease intracellular Na + and Ca 2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.