3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine

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3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:RO 4938581
CAS:883093-10-5
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:RO 4938581
CAS:883093-10-5
Package:25mg;1230USD|50mg;1610USD|100mg;2650USD
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
Tel: +86-0533-2185556 +8615965530500
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Products Intro: Product Name:RO4938581
Company Name: Shanghai Boyle Chemical Co., Ltd.  
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Products Intro: Product Name:RO4938581
CAS:883093-10-5
Company Name: DKMbiochem.Co. Ltd  
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Products Intro: Product Name:3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine
Purity:98% Package:1g,5g Remarks:Ro4938581

3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine manufacturers

  • RO 4938581
  • RO 4938581 pictures
  • $1230.00 / 25mg
  • 2026-04-17
  • CAS:883093-10-5
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  • Supply Ability: 10g
3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Basic information
Product Name:3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine
Synonyms:3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine;RO4938581;9H-Imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine, 3-bromo-10-(difluoromethyl)-
CAS:883093-10-5
MF:C13H8BrF2N5
MW:352.14
EINECS:
Product Categories:
Mol File:883093-10-5.mol
3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Structure
3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Chemical Properties
Boiling point 559.8±60.0 °C(Predicted)
density 1.93±0.1 g/cm3(Predicted)
form Solid
pka1.62±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Usage And Synthesis
UsesRO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
in vivo

RO 4938581 (0.3-1 mg/kg, p.o.) reverses a working memory impairment induced by scopolamine the delayed match to position (DMTP) task and a spatial learning impairment induced by diazepam (RO 4938581; 1-10 mg/kg, po)[1].

References[1] Knust H, et al. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. DOI:10.1016/j.bmcl.2009.08.053
3-broMo-10-(difluoroMethyl)-9H-benzo[f]iMidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]diazepine Preparation Products And Raw materials
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