- WS6
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- $30.00 / 1mg
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2025-04-27
- CAS:1421227-53-3
- Min. Order:
- Purity: 99.83%
- Supply Ability: 10g
- WS6
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- $1.00 / 1KG
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2020-01-03
- CAS:1421227-53-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200kg
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| Product Name: | WS6 | | Synonyms: | WS6, >=98%;N-(6-(4-(2-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYLAMINO)-2-OXOETHYL)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE;WS6;4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide;N-[6-[4-[2-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]phenoxy]pyrimidin-4-yl]cyclopropanecarboxamide WS6;WS6 N-(6-(4-(2-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYLAMINO)-2-OXOETHYL)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE;WS6, 1421227-53-3;N-(6-{4-[2-({4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}amino)-2-oxoethyl]phenoxy}-4-pyrimidinyl)cyclopropanecarboxamide | | CAS: | 1421227-53-3 | | MF: | C29H31F3N6O3 | | MW: | 568.59 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1421227-53-3.mol |  |
| Boiling point | 744.1±60.0 °C(Predicted) | | density | 1.374±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | pka | 11.82±0.20(Predicted) | | color | white to beige |
| Uses | WS6 is a β-cell proliferation indocer via the IκB kinase pathway and modulation of the Erb3 binding-protein. Potential treatment and cure for diabetes type I. | | Biological Activity | ws6 is a small-molecule inducer of β cell proliferation [1].β cells are a subset of cells in the pancreatic islets and play an important role in regulating glucose homeostasis through the production of insulin [1].ws6 is a small-molecule inducer of β cell proliferation. in mouse β cell line r7t1, ws6 induced cell proliferation with ec50 value of 0.28 μm. ws6 was very active in primary human and rodent islets. in primary rat and human β cells, ws6 induced rat β cell proliferation with ec50 value of 0.4 μm and increased 4% of rat β cells and 3% of human β cells to proliferate. in intact islet cultures, ws6 significantly induced proliferation [1]. in cultured human islets, ws6 induced β cell proliferation and also α cell proliferation. however, ws6 didn’t influence the expression of β cell-specific transcription factors and the amount of insulin-positive β cells, which suggested that ws6 didn’t influence β cell differentiation and human islet cell viability [2].in type 1 diabetes (t1d) mice, ws6 significantly reduced blood glucose and increased β cell proliferation from 3.8% to 6.4% [1]. | | in vivo | WS6 (2.2 mg/kg; once a day; 28 days; i.p.) alleviates depression like behavior in rats by enhancing GABA signaling and dendritic density in the hippocampus of chronic unpredictable mild stress (CUMS) model rats[2]. | Animal Model: | Wild type male Sprague Dawley rat model of chronic unpredictable mild stress (CUMS) induced depression[2]. | | Dosage: | 2.2 mg/kg | | Administration: | Intraperitoneal injection (i.p.); once a day; 28 days | | Result: | Reversed the reduction of neurogenesis, GABAergic neurons, dendritic complexity, spinal density, and synaptic plasticity associated protein 95 (PSD95) by CUMS. |
| | storage | Store at -20°C | | references | [1]. shen w, tremblay ms, deshmukh va, et al. small-molecule inducer of β cell proliferation identified by high-throughput screening. j am chem soc, 2013, 135(5): 1669-1672.
[2]. boerner bp, george nm, mir su, et al. ws6 induces both alpha and beta cell proliferation without affecting differentiation or viability. endocr j, 2015, 62(4): 379-386. |
| | WS6 Preparation Products And Raw materials |
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