| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
BSc2118 manufacturers
- BSc2118
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- $2500.00
-
2026-05-11
- CAS:863924-64-5
- Purity:
- Supply Ability: 10g
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| | BSc2118 Basic information |
| Product Name: | BSc2118 | | Synonyms: | BSc2118;L-α-Asparagine, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester | | CAS: | 863924-64-5 | | MF: | C28H43N3O7 | | MW: | 533.66 | | EINECS: | | | Product Categories: | | | Mol File: | 863924-64-5.mol |  |
| | BSc2118 Chemical Properties |
| Boiling point | 739.0±60.0 °C(Predicted) | | density | 1.113±0.06 g/cm3(Predicted) | | pka | 11.10±0.46(Predicted) |
| | BSc2118 Usage And Synthesis |
| Enzyme inhibitor | This potent aldehyde-containing tripeptide mimetic (FW = 533.31 g/mol; CAS 863924-64-5) targets the 20 S proteasome (with lowest IC50 values of 58 nm (chymotrypsin-like activity), 53 nm (trypsin-like activity), and 100 nm (caspase-like activity)), forming covalent adducts to active-site threonines. Given its critical role in protein turnover with effect on vital cellular pathways, the ubiquitin-proteasome system advanced to a promising new target in cancer treatment. Cell cycle regulating peptides, pro- and antiapoptotic proteins as well as transcription factors, all necessary for cell survival, are degraded proteasome-dependently. Proteasomal inhibition results in accumulation of myriad of regulatory proteins, leading to confounding signals toward cell cycle progression and induction of apoptosis. In OPM-2, RPMI-8226, U266 multiple myeloma (MM) cell lines and primary MM cells, BSc2118 causes dose-dependent growth inhibitory effects. After 48 hours, dose-dependent apoptosis occurs both in cell lines and primary myeloma cells. G2-M cell cycle arrest occurs after 24 hours, also causing marked inhibition of intracellular proteasome activity, an increase in intracellular p21 levels, and an inhibition of NF-kB activation. |
| | BSc2118 Preparation Products And Raw materials |
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