2-bromo-4-chloronicotinaldehyde manufacturers
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| | 2-bromo-4-chloronicotinaldehyde Basic information |
| Product Name: | 2-bromo-4-chloronicotinaldehyde | | Synonyms: | 2-bromo-4-chloronicotinaldehyde;2-Bromo-4-chloropyridine-3-carboxaldehyde;2-Bromo-4-chloropyridine-3-carboxaldehyde 97%;2-bromo-4-chloropyridine-3-carbaldehyde;3-Pyridinecarboxaldehyde, 2-bromo-4-chloro-;2-Bromo-4-chloropyridine-4-carboxaldehyde | | CAS: | 1289197-78-9 | | MF: | C6H3BrClNO | | MW: | 220.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1289197-78-9.mol |  |
| | 2-bromo-4-chloronicotinaldehyde Chemical Properties |
| Melting point | 83-87°C | | Boiling point | 283.2±35.0 °C(Predicted) | | density | 1.800±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | pka | -1.17±0.10(Predicted) | | Appearance | Off-white to yellow Solid | | InChI | InChI=1S/C6H3BrClNO/c7-6-4(3-10)5(8)1-2-9-6/h1-3H | | InChIKey | KCOAVFRTHTWKDO-UHFFFAOYSA-N | | SMILES | C1(Br)=NC=CC(Cl)=C1C=O |
| Hazard Codes | T,Xi | | Risk Statements | 25-36 | | Safety Statements | 26-45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | HS Code | 2933399990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2 |
| | 2-bromo-4-chloronicotinaldehyde Usage And Synthesis |
| Synthesis | GENERAL STEPS: To an anhydrous tetrahydrofuran (40 mL) solution of 2-bromo-4-chloropyridine (1.6 g, 8.0 mmol) was slowly added lithium diisopropylammonium solution (5.0 mL, 10.0 mmol, 2.0 M) over 5 minutes at -70 °C and stirring was continued for 1 hour at -70 °C. Subsequently, anhydrous N,N-dimethylformamide (1.3 g) was added dropwise over 3 minutes and the reaction mixture was stirred at the same temperature for another 30 minutes. After completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (30 mL) and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using petroleum ether/ethyl acetate (20:1) as eluent to afford 2-bromo-4-chloropyridine-3-carboxaldehyde (114a) as a yellow solid (900 mg, 48% yield).1H NMR (500 MHz, DMSO) δ 10.21 (s, 1H), 8.52 (d, J = 5.5 Hz, 1H), 7.79 (d, J = 5.0 Hz, 1H). | | References | [1] Patent: US2013/116262, 2013, A1. Location in patent: Paragraph 0307
[2] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0185
[3] Patent: US2013/116246, 2013, A1. Location in patent: Paragraph 0246 |
| | 2-bromo-4-chloronicotinaldehyde Preparation Products And Raw materials |
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