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| | 7-hydroxyquinoline-3-carboxylic acid Basic information |
| | 7-hydroxyquinoline-3-carboxylic acid Chemical Properties |
| Melting point | >260 °C | | Boiling point | 426.7±30.0 °C(Predicted) | | density | 1.480±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.34±0.30(Predicted) | | Appearance | Light yellow to yellow Solid |
| | 7-hydroxyquinoline-3-carboxylic acid Usage And Synthesis |
| Synthesis | Step E. Synthesis of 7-hydroxyquinoline-3-carboxylic acid. Ethyl 7-methoxyquinoline-3-carboxylate (7.03 g, 30.4 mmol) was dissolved in 48% aqueous hydrobromic acid (150 mL) and heated to reflux at 105 °C for 88.5 hours. After completion of the reaction, it was cooled to room temperature and the precipitate precipitated was collected by filtration to afford the title compound 7-hydroxyquinoline-3-carboxylic acid as a brown solid (5.2 g, 90% yield). 1H NMR (400 MHz, DMSO-d6) δ 12.05-11.67 (m, 1H), 9.49 (d, J = 2.0 Hz, 1H), 9.43 (s, 1H), 8.39 (d, J = 9.8 Hz, 1H), 7.55-7.51 (m, 2H). Mass spectrum (ESI) [M + H]+ m/z = 190.2. | | References | [1] Patent: US2014/275548, 2014, A1. Location in patent: Paragraph 0363 |
| | 7-hydroxyquinoline-3-carboxylic acid Preparation Products And Raw materials |
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