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4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

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Products Intro: Product Name:Palbociclib Impurity 42
CAS:119285-07-3
Purity:0.99 Package:10mg;25mg;50mg;100mg
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Products Intro: Product Name:tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate
CAS:119285-07-3
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-00457
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Products Intro: Product Name:tert-butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate
CAS:119285-07-3
Purity:0.97 Package:1KG;25KG
Company Name: ANHUI WITOP BIOTECH CO., LTD
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Products Intro: Product Name:ert-Butyl4-(5-amino-2-pyridinyl)tetrahydro-1(2H)-pyrazinecarboxylate
CAS:119285-07-3

4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Basic information
Product Name:4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms:1-BOC-4-(5-AMINO-PYRIDIN-2-YL)-PIPERAZINE;4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 4-(5-AMINO-2-PYRIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE;4-(5-Aminopyridin-2-yl)piperazine-1-carboxylicacidtert-butylester95%;4-(5-Aminopyridin-2-yl)qiperazine-1-carboxylic acid tert-butyl ester;4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%;4-(5-Aminopyridin-2-yl)piperazine, N1-BOC protected;1-Boc-4-(5-amino-2-pyridinyl)-piperazine
CAS:119285-07-3
MF:C14H22N4O2
MW:278.35
EINECS:
Product Categories:pharmacetical
Mol File:119285-07-3.mol
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Structure
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties
Melting point 98-101°C
Boiling point 470.4±45.0 °C(Predicted)
density 1.182±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka9.35±0.29(Predicted)
form solid
color black gel
Safety Information
Hazard Codes Xi,T
Risk Statements 25
Safety Statements 45
HazardClass IRRITANT
HS Code 2933599590
MSDS Information
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Usage And Synthesis
Synthesis
1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE

193902-78-2

4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

119285-07-3

Example 197b Synthesis of tert-butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate 197b: To a 250-mL round-bottomed flask under nitrogen protection was added 1-tert-butylcarbonyl-4-(5-nitro-2-piperidinyl)piperazine 197a (4.0 g, 13.0 mmol), 10% palladium-carbon (wetted, 500 mg) and methanol (130 mL). The reaction system was evacuated and filled with hydrogen and the reaction was stirred at room temperature for 15 hours. Upon completion of the reaction, the hydrogen was removed by evacuation and filled with nitrogen. The reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure to afford the target compound 197b (3.3 g, 91% yield). Mass spectral data (MS-ESI): [M + H]+ 279.

References[1] Patent: US2005/182078, 2005, A1. Location in patent: Page/Page column 9; 12
[2] Patent: WO2007/53394, 2007, A1. Location in patent: Page/Page column 14
[3] Chinese Chemical Letters, 2013, vol. 24, # 4, p. 303 - 306
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 16, p. 4779 - 4783
[5] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0753; 0755
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE-->1-(5-Nitropyridin-2-yl)piperazine-->2-Chloro-5-nitropyridine-->2-Bromo-5-nitropyridine-->Hydrogen-->1-BOC-Piperazine-->Activated carbon-->Methanol-->Palladium
Tag:4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(119285-07-3) Related Product Information
tert-butyl 4-(5-iodopyrimidin-2-yl)piperazine-1-carboxylate TERT-BUTYL 4-(5-FLUORO-2-METHOXYBENZYL)-4-HYDROXYPIPERIDINE-1-CARBOXYLATE 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE Palbociclib Impurity 7 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- Phosphine oxide, tris (2-methylphenyl)- tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester 5-(piperazin-1-yl)pyridin-2-aMine 571188-59-5 8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 1,4-bis(4-nitrophenyl)piperazine 1-(5-Nitropyridin-2-yl)piperazine 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one 1-BOC-4-(3-AMINO-4-PYRIDINYL)-PIPERAZINE 4-(6-Amino-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester tert-butyl 4-(3-nitropyridin-4-yl)piperazine-1-carboxylate