2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:ML303 CAS:1638211-04-7 Purity:99.80% Package:1mg;42USD\|5mg;98USD\|10mg;147USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354;
Email:	support@targetmol.com
Products Intro:	Product Name:ML303 CAS:1638211-04-7 Purity:99.80% Package:1mg;42USD\|5mg;98USD\|10mg;147USD

Company Name:	Wuhan Topule Biopharmaceutical Co., Ltd
Tel:	+8618327326525
Email:	masar@topule.com
Products Intro:	Product Name:ML303 CAS:1638211-04-7 Purity:98% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing

Company Name:	Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel:	+86-18341751992 +86-15382112998
Email:	757984502@qq.com
Products Intro:	Product Name:ML303 CAS:1638211-04-7 Purity:0.98 Package:100mg;500mg;1g;5g Remarks:existing product

Company Name:	Aladdin Scientific
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Email:	tp@aladdinsci.com
Products Intro:	Product Name:ML303 CAS:1638211-04-7 Purity:98% Package:$115.9/1mg;$268.9/5mg;$399.9/10mg;$659.9/25mg;Bulk package Remarks:98%

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol manufacturers

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Basic information

Product Name:	2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol
Synonyms:	2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol;ML303;ML 303,Influenza Virus,ML-303,ML303,inhibit,Inhibitor;Phenol, 2-methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-4-yl]-;ML303, 10 mM in DMSO
CAS:	1638211-04-7
MF:	C21H16F3N3O2
MW:	399.37
EINECS:
Product Categories:
Mol File:	1638211-04-7.mol

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Chemical Properties

Boiling point	483.6±45.0 °C(Predicted)
density	1.36±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 20mg/mL, clear
form	powder
pka	8.01±0.20(Predicted)
color	white to beige
InChI	1S/C21H16F3N3O2/c1-12-19-16(13-3-8-17(28)18(11-13)29-2)9-10-25-20(19)27(26-12)15-6-4-14(5-7-15)21(22,23)24/h3-11,28H,1-2H3
InChIKey	YBRHGNCGFMRGSV-UHFFFAOYSA-N
SMILES	CC1=NN(C2=CC=C(C(F)(F)F)C=C2)C3=NC=CC(C4=CC=C(O)C(OC)=C4)=C31

Safety Information

Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral

MSDS Information

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Usage And Synthesis

Uses	ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].
Biological Activity	It belongs to the pyrazolopyridine family.', 'ML303 is a potent inhibitor (IC50 = 155 nM) of the influenza viral protien NS1. NS1 enhances virulence by inhibiting host cell immune responses, including the expression of IFN-b, and regulating synthesis, splicing and translation of viral RNA.
References	[1] Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119. DOI:10.1016/j.bmcl.2019.02.027

2-Methoxy-4-(3-methyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)phenol Preparation Products And Raw materials

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