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| | Roof plate-specific spondin-3 Basic information |
| Product Name: | Roof plate-specific spondin-3 | | Synonyms: | Roof plate-specific spondin-3;RSPO3;R-SPONDIN-3 human;PWTSR;Recombinant Human RSPO3 Protein, His Tag;CRISTIN1;THSD2 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Roof plate-specific spondin-3 Structure]() |
| | Roof plate-specific spondin-3 Chemical Properties |
| storage temp. | -20°C | | form | lyophilized | | biological source | human |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Roof plate-specific spondin-3 Usage And Synthesis |
| Uses | The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, -catenin. This activity effectively activates and increases the subsequent nuclear signaling of -catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions. | | Biological Activity | The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. |
| | Roof plate-specific spondin-3 Preparation Products And Raw materials |
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