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| | N,N'-Dicyclohexyl-4-morpholinecarboxamidine Basic information |
| | N,N'-Dicyclohexyl-4-morpholinecarboxamidine Chemical Properties |
| Melting point | 105-107 °C(lit.) | | Boiling point | 423.2±55.0 °C(Predicted) | | density | 1.18±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 11.85±0.20(Predicted) | | color | White to Almost white | | InChI | 1S/C17H31N3O/c1-3-7-15(8-4-1)18-17(20-11-13-21-14-12-20)19-16-9-5-2-6-10-16/h15-16H,1-14H2,(H,18,19) | | InChIKey | OZNYZQOTXQSUJM-UHFFFAOYSA-N | | SMILES | C1CCC(CC1)N\C(=N\C2CCCCC2)N3CCOCC3 | | CAS DataBase Reference | 4975-73-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-24/25 | | WGK Germany | 3 | | RTECS | LQ4566500 | | HazardClass | IRRITANT | | HS Code | 29349990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | N,N'-Dicyclohexyl-4-morpholinecarboxamidine Usage And Synthesis |
| Chemical Properties | White powder | | Uses | N,N′-Dicyclohexyl-4-morpholinecarboxamidine was used as reagent in the synthesis of alkoxyalkyl analogs of nucleotide phosphonates, cidofovir and cyclic cidofovir. | | Application | N,N'-Dicyclohexyl-4-morpholinecarboxamidine is a strong base; it is used as a catalyst for phosphorylation reactions in nucleoside chemistry. | | Preparation | N,N'-Dicyclohexyl-4-morpholinecarboxamidine is easily prepared by refluxing morpholine and 1,3-Dicyclohexylcarbodiimide. | | General Description | N,N′-Dicyclohexyl-4-morpholinecarboxamidine is kidney-selective ATP-sensitive potassium blocker. It is an an orally effective nonkaliuretic diuretic in rats. | | Synthesis | GENERAL PROCEDURE: Morpholine (0.0128 g, 0.0075 mmol), N,N'-dicyclohexylcarbodiimide (0.189 g, 1.5 mmol), and aniline (0.140 g, 1.5 mmol) were added to a dry 10 mL Schlenk tube under argon protection. The reaction mixture was stirred at 25°C for 30 min. After completion of the reaction, the mixture was extracted with ether and a clarified solution was obtained by filtration. The solvent was evaporated under reduced pressure and the residue was recrystallized by ether to afford the white solid product N,N'-dicyclohexyl-4-morpholinecarboxamidine in >99% yield. | | References | [1] Journal of Organic Chemistry, 2008, vol. 73, # 22, p. 8966 - 8972
[2] Tetrahedron, 2011, vol. 67, # 45, p. 8790 - 8799
[3] Tetrahedron, 2012, vol. 68, # 29, p. 5730 - 5737
[4] Tetrahedron Letters, 2012, vol. 53, # 38, p. 5156 - 5158
[5] Journal of Organometallic Chemistry, 2014, vol. 769, p. 112 - 118 |
| | N,N'-Dicyclohexyl-4-morpholinecarboxamidine Preparation Products And Raw materials |
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