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| | O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Basic information |
| | O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Chemical Properties |
| Melting point | 227 °C (subl.)(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | H2O: 5%, clear | | form | powder to crystal | | color | White | | PH | pH(5g/l, 25℃) : 2.0～3.0 | | Water Solubility | Soluble in water. | | BRN | 4031190 | | CAS DataBase Reference | 57981-02-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10 | | HazardClass | IRRITANT | | HS Code | 29280000 |
| | O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White powder | | Uses | O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride is used in the preparation of oximes of steroids having keto group. It is used as a derivatization reagent in the determination of thromboxane B2, prostaglandins, amygdalin and a variety of aldehydes, ketones and acids. It is a versatile reagent utilized for the detection of carbonyl-containing compounds by gas chromatography (GC), gas chromatography mass spectrometry (GC-MS) and other methods. As a derivatization reagent, it is also used for EC/LC analysis of keto-steroids and carbohydrates. | | Uses | PFBHA.HCl has been used for derivatization of metabolites with carbonyl groups followed by analysis via GC-MS. It has also been used in aldehyde derivatization followed by aldehydic hydrolysis using GC/MS. | | Uses | O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride is used:
- In the preparation of oximes of steroids-bearing keto group.
- As a derivatization reagent in the determination of thromboxane B2, prostaglandins, amygdalin, and a variety of aldehydes, ketones, and acids.
It is a versatile reagent used for the detection of carbonyl-containing compounds by GC, GC-MS, and other methods. | | General Description | O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA.HCl) is a derivatizing agent. | | reaction suitability | reagent type: derivatization reagent
reaction type: Alkylations | | Purification Methods | Recrystallise the salt from EtOH to form colourless leaflets. Drying the compound at high vacuum and elevated temperature will result in losses by sublimation. [Youngdale J Pharm Sci 65 625 1976, Wehner & Handke J Chromatog 177 237 1979, Nambara et al. give incorrect m as 115-116o J Chromatogr 114 81 1975.] |
| | O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Preparation Products And Raw materials |
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