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| | 5,6-DICHLORO-2-METHYLBENZIMIDAZOLE Basic information |
| Product Name: | 5,6-DICHLORO-2-METHYLBENZIMIDAZOLE | | Synonyms: | 5,6-DICHLORO-2-METHYL-1H-BENZIMIDAZOLE;5,6-DICHLORO-2-METHYL-1H-BENZO[D]IMIDAZOLE;5,6-DICHLORO-2-METHYLBENZIMIDAZOLE;BUTTPARK 147\15-46;5,6-Dichloro-2-methylbenzoimidazole;5,6-dichloro-2-Methyl-1H-1,3-benzodiazole;5,6-Dichloro-2-methylbenzimidazole>;1H-Benzimidazole, 5,6-dichloro-2-methyl- | | CAS: | 6478-79-1 | | MF: | C8H6Cl2N2 | | MW: | 201.05 | | EINECS: | | | Product Categories: | Imidazol&Benzimidazole;Aromatics;Heterocycles;Intermediates | | Mol File: | 6478-79-1.mol |  |
| | 5,6-DICHLORO-2-METHYLBENZIMIDAZOLE Chemical Properties |
| Melting point | 238-240 | | Boiling point | 409.0±25.0 °C(Predicted) | | density | 1.486 | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | pka | 9.94±0.10(Predicted) | | form | powder to crystal | | color | White to Orange to Green | | CAS DataBase Reference | 6478-79-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2933998090 |
| | 5,6-DICHLORO-2-METHYLBENZIMIDAZOLE Usage And Synthesis |
| Uses | 5,6-Dichloro-2-methylbenzimidazole is a benzimidazole with antiparasitic activity. It also shows aminopyrine demethylase-inhibiting activity. | | Synthesis | GENERAL METHOD: A mixture of 4,5-dichloro-1,2-phenylenediamine (200 mg, 1.85 mmol) and ethyl acetoacetate (722 mg, 5.55 mmol) was added with GdCl3-6H2O (25 mg, 0.09 mmol), and the reaction mixture was stirred for 3.0 hours at 80 °C. After completion of the reaction (monitored by TLC), the reaction mixture was poured into ice-cold water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 5,6-dichloro-2-methylbenzimidazole crude. The crude product was further purified by column chromatography with the eluent being a hexane solution of 10% ethyl acetate. | | References | [1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2015, vol. 54B, # 8, p. 953 - 957 |
| | 5,6-DICHLORO-2-METHYLBENZIMIDAZOLE Preparation Products And Raw materials |
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