BX 430
| 中文名称 | BX 430 |
|---|---|
| 中文同义词 | 化合物BX430;1-(2,6-二溴-4-异丙基苯基)-3-(吡啶-3-基)脲;BX 430,P2X4变构拮抗剂;化合物BX430,10 MM DMSO 溶液 |
| 英文名称 | BX 430 |
| 英文同义词 | BX 430;N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea;Urea, N-[2,6-dibromo-4-(1-methylethyl)phenyl]-N'-3-pyridinyl-;1-(2,6-Dibromo-4-isopropylphenyl)-3-(pyridin-3-yl)urea;P2X Receptor,Ca channels,BX430,chronic,channels,species,P2XRs,Inhibitor,disease,Ca2+ channels,BX 430,cardiovascular,P2X4,receptor,specificity,inhibit,Calcium Channel,human,pain,BX-430;BX430, 10 mM in DMSO |
| CAS号 | 688309-70-8 |
| 分子式 | C15H15Br2N3O |
| 分子量 | 413.11 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 688309-70-8.mol |
| 结构式 |  |
BX 430 性质
| 熔点 | 164-168°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色 |
| InChI | 1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21) |
| InChIKey | JFNKIJKRXKPQCC-UHFFFAOYSA-N |
| SMILES | BrC1=CC(C(C)C)=CC(Br)=C1NC(NC2=CC=CN=C2)=O |
BX430 是一种有效的、选择性的、非竞争性 human P2X4 receptor 通道的变构拮抗剂，IC50值为0.54 μM。BX430 是对斑马鱼P2X4有效的拮抗剂，但对大鼠和小鼠P2X4直系同源物没有作用。BX430 可用于慢性疼痛和心血管疾病。
| Target | Value |
|
hP2X4
(Cell-free assay) | 0.54 μM |
BX430 has virtually no functional impact on all other P2X subtypes, namely, P2X1-P2X3, P2X5, and P2X7, at 10-100 times its IC
50
.
BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs.
Human P2X4-expressing cells treated with thapsigargin plus BX430 shows a significant reduction in the intracellular calcium rise evoked by ATP.
BX430 (5 μM) markedly reduces the amplitude of ATP-evoked intracellular calcium responses in THP-1 cells.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-110237 | BX 430 BX430 | 688309-70-8 | 1 mg | 224元 |
| 2026/09/15 | HY-110237 | BX 430 BX430 | 688309-70-8 | 5mg | 516元 |