N-Me-L-Ala-maytansinol manufacturers
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| | N-Me-L-Ala-maytansinol Basic information |
| Product Name: | N-Me-L-Ala-maytansinol | | Synonyms: | AP3 Intermidate 1;maytansinol 3-(S)-α-N-methylaminopropionate;AP3 Intermidate;N-Me-L-Ala-maytansinol;Maytansine, N2'-deacetyl-;Benzoicacid,4-fluoro-,(5-bromo-4-methoxyphenyl)methylester;(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl (2S)-2-(methylamino)propanoate | | CAS: | 77668-69-0 | | MF: | C32H44ClN3O9 | | MW: | 650.17 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 77668-69-0.mol |  |
| | N-Me-L-Ala-maytansinol Chemical Properties |
| Boiling point | 849.5±65.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | form | Solid | | pka | 9.82±0.70(Predicted) | | color | White to off-white | | InChIKey | ANHBJISROJTYCJ-CYVYAHHPNA-N |
| | N-Me-L-Ala-maytansinol Usage And Synthesis |
| Description | Maytansinoid-Ala is a potent microtubule-targeted compound that inhibits proliferation of cells at mitosis. Maytansinoid-Ala can be used for synthesis of ADCs. The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. | | Uses | N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used for making antibody-drug conjugate (ADC)[1]. | | IC 50 | Maytansinoids | | References | [1] Nittoli T, et al. Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. DOI:10.1016/j.bmc.2018.02.025 |
| | N-Me-L-Ala-maytansinol Preparation Products And Raw materials |
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