8-Nitrotryptanthrin

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8-Nitrotryptanthrin Suppliers list
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
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Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 15026964105
Email: 2881489226@qq.com
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 177-54423994 17754423994
Email: 2853530910@QQ.com
Company Name: Musechem  
Tel: +1-800-259-7612
Email: info@musechem.com

8-Nitrotryptanthrin manufacturers

  • GNF-PF-3777
  • GNF-PF-3777 pictures
  • $38.00
  • 2026-07-27
  • CAS:77603-42-0
  • Purity: 99.47%
  • Supply Ability: 10g
  • GNF-PF-3777
  • GNF-PF-3777 pictures
  • $38.00
  • 2026-07-27
  • CAS:77603-42-0
  • Purity: 99.47%
  • Supply Ability: 10g
  • GNF-PF-3777
  • GNF-PF-3777 pictures
  • $30.00
  • 2025-05-12
  • CAS:77603-42-0
  • Purity: 97.88%
  • Supply Ability: 10g
8-Nitrotryptanthrin Basic information
Product Name:8-Nitrotryptanthrin
Synonyms:8-Nitrotryptanthrin;GNF-PF-3777;Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-;GNF-PF-3777 (8-Nitrotryptanthrin);GNFPF3777,GNF PF 3777,Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO);8-Nitroindolo[2,1-b]quinazoline-6,12-dione;NF-PF-3777;GNF-PF-3777, 10 mM in DMSO
CAS:77603-42-0
MF:C15H7N3O4
MW:293.23
EINECS:
Product Categories:
Mol File:77603-42-0.mol
8-Nitrotryptanthrin Structure
8-Nitrotryptanthrin Chemical Properties
Melting point >250 °C
Boiling point 551.2±52.0 °C(Predicted)
density 1.67±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO:4.2(Max Conc. mg/mL);14.32(Max Conc. mM)
form A crystalline solid
pka-7.55±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
8-Nitrotryptanthrin Usage And Synthesis
UsesGNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
IC 50rhIDO2: 1.8 μM (IC50); rhIDO2: 0.97 μM (Ki)
References[1] Li J, et al. Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-9. DOI:10.1016/j.ejmech.2016.07.013
[2] Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46(3):882-3. DOI:10.1128/AAC.46.3.882-883.2002
[3] Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76(3):354-67. DOI:10.1021/np3007167
8-Nitrotryptanthrin Preparation Products And Raw materials
Tag:8-Nitrotryptanthrin(77603-42-0) Related Product Information
1-Methyl-D-tryptophan Β-LAPACHONE IDO-IN-1 IDO-IN-7 indoleaMine-2,3-dioxygenase inhibitor INCB024360 NLG919 IDO-IN-4 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione IDO-IN-3