- SF2523
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- $72.00
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2026-07-27
- CAS:1174428-47-7
- Purity: 99.51%
- Supply Ability: 10g
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| Product Name: | SF2523 | | Synonyms: | SF2523;SF-2523;3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-morpholino-7H-thieno[3,2-b]pyran-7-one;SF-2523; SF 2523;CS-2518;7H-Thieno[3,2-b]pyran-7-one, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(4-morpholinyl)-;SF 2523,Inhibitor,PI3K,SF-2523,Phosphoinositide 3-kinase,Epigenetic Reader Domain,DNA-dependent protein kinase,DNA-PK,inhibit,SF2523;SF2523, 10 mM in DMSO | | CAS: | 1174428-47-7 | | MF: | C19H17NO5S | | MW: | 371.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1174428-47-7.mol |  |
| | SF2523 Chemical Properties |
| Boiling point | 538.0±50.0 °C(Predicted) | | density | 1.423±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:10.0(Max Conc. mg/mL);26.92(Max Conc. mM)
DMSO:29.5(Max Conc. mg/mL);79.43(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.27(Max Conc. mM)
Ethanol:7.0(Max Conc. mg/mL);18.85(Max Conc. mM) | | form | A crystalline solid | | pka | 0.55±0.20(Predicted) | | color | Light yellow to khaki |
| | SF2523 Usage And Synthesis |
| Uses | SF2523 is a dual action inhibitor that blocks tumor growth and metastasis and for the development of anticancer therapy. | | in vivo | SF2523 treatment results in a significant reduction of tumor volume compared with control. Importantly, SF2523 shows no gross toxicity to the treated mice, as there is no notable change in body weight. Tumors from SF2523-treated mice have markedly reduced MYCN, pAKT, and Cyclin D1 levels compared with levels of these proteins in vehicle-treated mice tumors[2]. | | IC 50 | PI3Kα: 34 nM (IC50); PI3Kγ: 158 nM (IC50); BRD4 (BD1): 241 nM (IC50); DNA-PK: 9 nM (IC50); mTOR: 280 nM (IC50) |
| | SF2523 Preparation Products And Raw materials |
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