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ASB14780 manufacturers
- ASB 14780
-
- $197.00
-
2026-08-12
- CAS:1069046-00-9
- Purity: 99.71%
- Supply Ability: 10g
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| | ASB14780 Basic information |
| Product Name: | ASB14780 | | Synonyms: | ASB14780;ASB 14780
(ASB14780;ASB14780 >=98% (HPLC);ASB 14780New | | CAS: | 1069046-00-9 | | MF: | C35H38N2O6 | | MW: | 582.7 | | EINECS: | | | Product Categories: | | | Mol File: | 1069046-00-9.mol |  |
| | ASB14780 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO|58.27|100| | | form | Solid | | color | White to off-white | | InChIKey | MBPXGBINIINSEU-UHFFFAOYSA-N | | SMILES | O=C(O)CCC1=CC2=C(N(C3=CC=C(OC4=CC=CC=C4)C=C3)C=C2CCC5=CC=CC=C5)C=C1.NC(CO)(CO)CO |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | ASB14780 Usage And Synthesis |
| Description | ASB14780 is a potent inhibitor of cPLA2α. | | Uses | ASB14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A2α (cPLA2α) inhibitor, with an IC50 value of 20 nM[1]. | | in vivo | TPA (tetradecanoyl phorbol acetate) causes acute inflammation with ear, resulting in edema[1].
ASB14780 (50 mg/kg; p.o.; once) suppresses the increase in the ear thickness elicited by the application of TPA (tetradecanoyl phorbol acetate) in mouse[1].
ASB14780 (5 mg/kg; 20 mg/kg; p.o.; once daily) attenuates AHR (airway hyperreactivity), and inhibits IAR (immediate asthmatic response) and LAR (late asthmatic response) in a dose-dependent manner[1].
ASB14780 shows well oral activity of 89.6% in mouse calculated from the ratio of oral administration’s AUC (10 mg/kg; p.o.) and intravenonous administration’s AUC (1 mg/kg; i.v.)[1].
Oral Bioavailabilities and Pharmacokinetic Parameters of ASB14780[1]
| Model | F (%) | AUC (h μg/mL) | Cmax (μg/mL) | | mouse | 89.6 | 7.12 | 5.12 | | dog | 34.3 | 17.1 | 4.96 | | monkey | 30.9 | 4.96 | 2.29 |
Note: Based on 10 mg/kg p.o. dosing data.
| Animal Model: | TPA (Tetradecanoyl Phorbol Acetate)-induced Ear Edema Model in mouse (female C57BL/6 mice)[1] | | Dosage: | 50 mg/kg | | Administration: | Oral gavage; 30 min before TPA stimulation | | Result: | Showed high potency and inhibited ear swelling by 30% and indicated the in vivo anti-inflammatory activity.
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| Animal Model: | Guinea Pig Ovalbumin (OVA)-induced Asthma Model[1] | | Dosage: | 5 mg/kg, 20 mg/kg | | Administration: | Oral gavage; two single doses; 1 h before and 8 h after passively sensitized administration | | Result: | Exhibits suppression on IAR (immediate asthmatic response) and LAR (late asthmatic response) in a dose-dependent manner.
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| | storage | Store at -20°C | | References | [1] Tomoo T, et al. Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors. J Med Chem. 2014. 57(17):7244-62. DOI:10.1021/jm500494y |
| | ASB14780 Preparation Products And Raw materials |
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