| Company Name: |
Rhawn Reagent |
| Tel: |
400-400-1332688 18019345275 |
| Email: |
huyue@rhawn.cn |
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| | 3-methoxycarbonylcyclopentane-1-carboxylic Acid Basic information |
| | 3-methoxycarbonylcyclopentane-1-carboxylic Acid Chemical Properties |
| Boiling point | 286.4±33.0 °C(Predicted) | | density | 1.242±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.51±0.40(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | 3-methoxycarbonylcyclopentane-1-carboxylic Acid Usage And Synthesis |
| Synthesis | To a methanolic (35 mL) suspension of 3-oxabicyclo[3.2.1]octane-2,4-dione (3.0 g, 21 mmol) was added sodium methanolate (1.2 g, 21 mmol) in batches at room temperature. After 1 h of reaction, the resulting clarified solution was evaporated, alkalized with 1 M NaOH solution and washed twice with ethyl acetate (EtOAc). Subsequently, the aqueous layer was acidified with 1N HCl to pH about 2 and extracted with dichloromethane (CH2Cl2, 3 x 25 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and evaporated to afford 3-(methoxycarbonyl)cyclopentane-1-carboxylic acid (2.7 g, 75%) as a clear oil. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.70 (s, 3H), 2.76-2.94 (m, 2H), 2.28 (dt, J = 13.3, 8.0 Hz, 1H), 2.15 (dt, J = 13.3, 9.1 Hz, 1H), 1.89-2.07 (m, 4H). The mass spectrum (APCI+) showed a m/z of 173.2 (C8H12O4, M+H)+. | | References | [1] Patent: WO2015/166373, 2015, A1. Location in patent: Page/Page column 147; 148 |
| | 3-methoxycarbonylcyclopentane-1-carboxylic Acid Preparation Products And Raw materials |
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