KISS-1 (68-121) manufacturers
- KISS-1 (68-121)
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- $7.00 / 1KG
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2020-02-17
- CAS: 374683-24-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100KG
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| | KISS-1 (68-121) Basic information |
| Product Name: | KISS-1 (68-121) | | Synonyms: | H-GLY-THR-SER-LEU-SER-PRO-PRO-PRO-GLU-SER-SER-GLY-SER-ARG-GLN-GLN-PRO-GLY-LEU-SER-ALA-PRO-HIS-SER-ARG-GLN-ILE-PRO-ALA-PRO-GLN-GLY-ALA-VAL-LEU-VAL-GLN-ARG-GLU-LYS-ASP-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2;MALIGNANT MELANOMA METASTASIS-SUPPRESSOR KISS-1 (68-121) (HUMAN);Kisspeptin-54 (huMan)
Metastin (huMan), Malignant MelanoMa Metastasis-Suppressor KiSS-1 (68-121) (huMan), KiSS-1 (68-121) (huMan);Metastin (huMan), Malignant MelanoMa Metastasis-Suppressor KiSS-1 (68-121) (huMan), KiSS-1 (68-121) (huMan);KISS-1 (68-121);KISSPEPTIN-54;METASTIN;METASTIN (HUMAN) | | CAS: | 374683-24-6 | | MF: | C258H401N79O78 | | MW: | 5857.42704 | | EINECS: | | | Product Categories: | | | Mol File: | 374683-24-6.mol |  |
| | KISS-1 (68-121) Chemical Properties |
| storage temp. | Desiccate at -20°C | | form | Solid | | color | White to off-white | | Water Solubility | Soluble to 1 mg/ml in Water |
| | KISS-1 (68-121) Usage And Synthesis |
| Uses | Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and human GPR54 receptors with Ki values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone[1][2][3][4][5][6][7][8]. | | in vivo | Kisspeptin-54(human) (0.3-100 nmol/kg, i.p., 30 min before trunk blood and anterior pituitaries are collected) dose-dependently shows activation of the anterior pituitary release of LH in post-pubertal male rats[6].
Kisspeptin-54(human) (0.3-30 nmol/kg, i.p.) produces a dose-dependent effect on c-fos mRNA levels in the anterior pituitary in various ages (PND15, PND30, and PND45) male rats[6].
Kisspeptin-54(human) (0.1-30 nmol/kg, i.p., single) increases serum testosterone in mice, with the same potency as for mouse kisspeptins[7].
Kisspeptin-54(human) (6.7 nmol/rat, s.c.) induces the release of gonadotropin via activation of the hypothalamic GnRH neurons in prepubertal female rats[8].
| Animal Model: | Post-pubertal male rats[6] | | Dosage: | 0.3, 1.0, 3.0, 10, 30 and 100 nmol/kg | | Administration: | Intraperitoneal injection (i.p.), 30 min before trunk blood and anterior pituitaries are collected | | Result: | Elevated c-fos gene expression, as well as the plasma concentrations of LH and testosterone.
Showed no overall statistical effect on plasma testosterone.
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| | storage | Store at -20°C | | References | [1] M L Gottsch, et al. A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse. Endocrinology. 2004 Sep;145(9):4073-7. DOI:10.1210/en.2004-0431
[2] M Kotani, et al. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-Coupled Receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6. DOI:10.1074/jbc.M104847200
[3] Nakamura Y, et al. Metastin stimulates aldosterone synthesis in human adrenal cells. Reprod Sci. 2007 Dec;14(8):836-45. DOI:10.1177/1933719107307823
[4] Masui T, et al. Metastin and its variant forms suppress migration of pancreatic cancer cells. Biochem Biophys Res Commun. 2004 Feb 27;315(1):85-92. DOI:10.1016/j.bbrc.2004.01.021
[5] Shoji S, et al. Metastin inhibits migration and invasion of renal cell carcinoma with overexpression of metastin receptor. European urology, 2009, 55(2): 441-451.
[6] Bentsen AH, et al. Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. Peptides. 2010 Feb;31(2):275-83. DOI:10.1016/j.peptides.2009.11.017
[7] Mikkelsen JD, et al. Comparison of the effects of peripherally administered kisspeptins. Regul Pept. 2009 Jan 8;152(1-3):95-100. DOI:10.1016/j.regpep.2008.10.001
[8] Matsui H, et al. Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun. 2004 Jul 23;320(2):383-8. DOI:10.1016/j.bbrc.2004.05.185 |
| | KISS-1 (68-121) Preparation Products And Raw materials |
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