|
|
| | 2-Thiazolesulfonyl chloride Basic information |
| | 2-Thiazolesulfonyl chloride Chemical Properties |
| Boiling point | 328.5±25.0 °C(Predicted) | | density | 1.687±0.06 g/cm3(Predicted) | | storage temp. | -86°C Freezer, Under Inert Atmosphere | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | | form | Oil | | pka | -3.33±0.10(Predicted) | | color | Clear Pale Yellow to Yellow |
| | 2-Thiazolesulfonyl chloride Usage And Synthesis |
| Chemical Properties | Yellow Oil | | Uses | 2-Thiazolesulfonyl chloride is used for preparation of substituted thiazolesulfonamides as antiglaucoma agents. | | Synthesis | To a suspension of 2-mercaptothiazole (0.16 g, 1.37 mmol) in CH2Cl2 (14 mL) was added water (7 mL) followed by N-chlorosuccinimide (0.75 g, 5.6 mmol). The reaction mixture was stirred vigorously for 1.5 h. The reaction mixture was diluted with CH2Cl2, washed with saturated aqueous NaHCO3, dried and concentrated in vacuo to give 2-thiazolesulfonyl chloride in a yield of 0.25g. |
| | 2-Thiazolesulfonyl chloride Preparation Products And Raw materials |
|