| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
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| Product Name: | HUMAN IL-4 | | Synonyms: | HUMAN BSF-1;INTERLEUKIN-4, HUMAN, RECOMBINANT;INTERLEUKIN-4, HUMAN, RECOMBINANT, E COLI;INTERLEUKIN-4, HUMAN;IL-4, HUMAN;HUMAN B CELL STIMULATING FACTOR;HUMAN IL-4;HUMAN INTERLEUKIN-4 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![HUMAN IL-4 Structure]() |
| | HUMAN IL-4 Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder | | color | white | | biological source | mouse |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | HUMAN IL-4 Usage And Synthesis |
| Uses | Lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and βFGF-induced angiogenesis. | | Uses | IL-4 (interleukin 4) has been used to polarize the human monocytic leukemia (THP-1) cells to M2-like phenotype. | | Uses | Interleukin-4 (IL-4) has been used as a stimulant of M2 state of microglia that is associated with wound healing and debris clearance. | | General Description | IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues. | | Biochem/physiol Actions | IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues. | | Description | Interleukin-4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 15kDa.
The IL-4 is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli |
| | HUMAN IL-4 Preparation Products And Raw materials |
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