1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]-

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1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]- manufacturers

  • IMB-301
  • IMB-301 pictures
  • $41.00
  • 2026-07-27
  • CAS:64009-84-3
  • Purity: 99.72%
  • Supply Ability: 10g
1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]- Basic information
Product Name:1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]-
Synonyms:1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]-;IMB-301;Inhibitor,APOBEC3G,HIV-1,inhibit,Human immunodeficiency virus,IMB 301,HIV,IMB-301,replication,IMB301,hA3G-Vif;1-(2-(2,4-Dichlorophenyl)-4-(4-fluorophenoxy)butyl)-1H-imidazole;IMB-301, 10 mM in DMSO
CAS:64009-84-3
MF:C19H17Cl2FN2O
MW:379.26
EINECS:
Product Categories:
Mol File:64009-84-3.mol
1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]- Structure
1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]- Chemical Properties
Boiling point 548.1±50.0 °C(Predicted)
density 1.27±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka6.82±0.12(Predicted)
form Oil
color Colorless to light yellow
Safety Information
MSDS Information
1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]- Usage And Synthesis
UsesIMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G), interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3G. IMB-301 inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM). Human APOBEC3G is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication[1].
References[1] Ma L, et al. Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep. 2018;8(1):8067. Published 2018 May 23. DOI:10.1038/s41598-018-26318-3
1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]- Preparation Products And Raw materials
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