1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione
| 中文名称 | 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione |
|---|---|
| 中文同义词 | 阿糖胞苷杂质17;阿糖胞苷杂质28;化合物 5-HYDROXY-ARABINOURIDINE |
| 英文名称 | 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione |
| 英文同义词 | 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione;5-Hydroxy-arabinouridine;Cytarabine Impurity 17;1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydroxypyrimidine-2,4(1H,3H)-dione;Cytarabine Impurity 28;2,4(1H,3H)-Pyrimidinedione, 1-β-D-arabinofuranosyl-5-hydroxy-;Cytarabine 19 |
| CAS号 | 69321-95-5 |
| 分子式 | C9H12N2O7 |
| 分子量 | 260.20078 |
| EINECS号 | |
| 相关类别 | 杂质对照品 |
| Mol文件 | 69321-95-5.mol |
| 结构式 | ![1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione 结构式](CAS/20180601/GIF/69321-95-5.gif) |
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione 性质
| 密度 | 1.848±0.06 g/cm3(Predicted) |
|---|---|
| 酸度系数(pKa) | 8?+-.0.20(Predicted) |
5-Hydroxy-arabinouridine 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性，靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等。