Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- manufacturers

  • ESI-05
  • ESI-05 pictures
  • $33.00
  • 2026-07-14
  • CAS:5184-64-5
  • Purity: 98.00%
  • Supply Ability: 10g
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Basic information
Product Name:Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
Synonyms:Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;MESITYL P-TOLYL SULFONE;ESI-05;ESI-05 (ESI05);1,3,5-trimethyl-2-tosylbenzene;NSC 116966;ESI-05 >=98% (HPLC)
CAS:5184-64-5
MF:C16H18O2S
MW:274.38
EINECS:
Product Categories:
Mol File:5184-64-5.mol
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Structure
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemical Properties
Melting point 119-120 °C
Boiling point 426.7±45.0 °C(Predicted)
density 1.129±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: soluble
form powder
color white to beige
Safety Information
MSDS Information
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Usage And Synthesis
UsesESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.
Biochem/physiol ActionsESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.
in vivo

ESI-05 (2, 4, and 8 mg/kg) decreases neuronal apoptosis by inhibiting the p38/BIM pathway in vivo[2].

Animal Model:Intracranial hemorrhage (ICH) model[2]
Dosage:2, 4, and 8 mg/kg
Administration:
Result:Decreased the apoptosis rate of nerve cells in the cortex accompanied by a corresponding decrease in the protein expression of phosphorylated p38, Bcl-2like protein 11 (BIM), and caspase-3.
storageStore at RT
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials
Tag:Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-(5184-64-5) Related Product Information
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