UR-PI376 manufacturers
- UR-PI376
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- $1980.00
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2026-04-20
- CAS:1192559-94-6
- Purity:
- Supply Ability: 10g
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| | UR-PI376 Basic information |
| Product Name: | UR-PI376 | | Synonyms: | UR-PI376;URPI376,UR PI376;Guanidine, N-cyano-N''-[4-(1H-imidazol-5-yl)butyl]-N'-[2-(phenylthio)ethyl]- | | CAS: | 1192559-94-6 | | MF: | C17H22N6S | | MW: | 342.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1192559-94-6.mol |  |
| | UR-PI376 Chemical Properties |
| Boiling point | 585.0±60.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | pka | 14.23±0.10(Predicted) |
| | UR-PI376 Usage And Synthesis |
| Description | UR-PI376 is a histamine H4 receptor agonist ( hH4R agonist) (pEC50 = 7.47, alpha = 0.93) showing negligible hH1R and hH2R activities and significant selectivity over the hH3R (pKB = 6.00, alpha = -0.28), as determined in steady-state GTPase assays using membrane preparations of hH(x)R-expressing Sf9 cells. Modeling of the binding mode of UR-PI376 suggests that the cyanoguanidine moiety forms charge-assisted hydrogen bonds not only with the conserved Asp-94 but also with the hH4R-specific Arg-341 residue. | | Uses | UR-PI376 is a potent and selective histamine H4 receptor (H4R) agonist with a pEC50 value of 7.47. UR-PI376 shows negligible hH1R and hH2R activities and moderate inverse agonistic activity at the hH3R[1]. | | IC 50 | Human H4 Receptor: 7.47 (pEC50) | | References | [1] Patrick Igel, et al. Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. J Med Chem. 2009 Oct 22;52(20):6297-313. DOI:10.1021/jm900526h |
| | UR-PI376 Preparation Products And Raw materials |
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