AU1235 manufacturers
- AU1235
-
- $68.00 / 1mg
-
2026-04-10
- CAS:1338780-86-1
- Min. Order:
- Purity: 99.78%
- Supply Ability: 10g
- AU1235
-
- $68.00 / 1mg
-
2026-04-10
- CAS:1338780-86-1
- Min. Order:
- Purity: 99.78%
- Supply Ability: 10g
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| Product Name: | AU1235 | | Synonyms: | AU1235;AU1235;AU-1235;AU 1235;Urea, N-tricyclo[3.3.1.13,7]dec-1-yl-N'-(2,3,4-trifluorophenyl)-;Inhibitor,MmpL3,transport,tuberculosis,AU1235,cell,AU 1235,AU-1235,synthesis,inhibit,Bacterial,wall,Mycobacterium;AU1235, 10 mM in DMSO;1-(Adamantan-1-yl)-3-(2,3,4-trifluorophenyl)urea | | CAS: | 1338780-86-1 | | MF: | C17H19F3N2O | | MW: | 324.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1338780-86-1.mol |  |
| | AU1235 Chemical Properties |
| Boiling point | 377.7±42.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 6 mg/mL (18.50 mM) | | form | Solid | | pka | 12.02±0.70(Predicted) | | color | White to off-white |
| | AU1235 Usage And Synthesis |
| Uses | AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2]. | | References | [1] McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5(5):e00985-20. Published 2020 Oct 14. DOI:10.1128/mSphere.00985-20
[2] Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8(4):334-341. Published 2012 Feb 19. DOI:10.1038/nchembio.794 |
| | AU1235 Preparation Products And Raw materials |
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