t-Boc-N-amido-PEG5-NHS ester manufacturers
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| | t-Boc-N-amido-PEG5-NHS ester Basic information |
| Product Name: | t-Boc-N-amido-PEG5-NHS ester | | Synonyms: | t-Boc-N-amido-PEG5-NHS ester;BocNH-PEG5-CH2CH2COONHS;Boc-N-PEG5-C2-NHS ester;BocNH-PEG5-CH2CH2COONHS/5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid, 1-(1,1-dimethylethyl) 20-(2,5-dioxo-1-pyrrolidinyl) ester;5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid, 1-(1,1-dimethylethyl) 20-(2,5-dioxo-1-pyrrolidinyl) ester;2,5-Dioxopyrrolidin-1-yl 2,2-dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oate;BocNH-PEG5-CH2CH2COONHS ester;t-Boc-N-amido-PEG5-NHS | | CAS: | 2055040-78-1 | | MF: | C22H38N2O11 | | MW: | 506.54 | | EINECS: | | | Product Categories: | | | Mol File: | 2055040-78-1.mol |  |
| | t-Boc-N-amido-PEG5-NHS ester Chemical Properties |
| density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Storage temp. -20°C | | form | Liquid | | pka | 12.23±0.46(Predicted) | | color | Colorless to light yellow |
| | t-Boc-N-amido-PEG5-NHS ester Usage And Synthesis |
| Description | t-Boc-N-amido-PEG5-NHS ester is a PEG linker containing an NHS ester and a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc group can be deprotected under mild acidic conditions to form the free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | | Uses | Boc-N-PEG5-C2-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
| | t-Boc-N-amido-PEG5-NHS ester Preparation Products And Raw materials |
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