ODZXEQVQLJKSQH-UHFFFAOYSA-N manufacturers
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| | ODZXEQVQLJKSQH-UHFFFAOYSA-N Basic information |
| Product Name: | ODZXEQVQLJKSQH-UHFFFAOYSA-N | | Synonyms: | ODZXEQVQLJKSQH-UHFFFAOYSA-N;1H-Isoindole-1,3(2H)-dione, 5-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1);5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride;5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride;Thalidomide-5-CH2-NH2 (hydrochloride);5-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, HCl salt;5-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochlorde | | CAS: | 1010100-22-7 | | MF: | C14H14ClN3O4 | | MW: | 323.73 | | EINECS: | | | Product Categories: | | | Mol File: | 1010100-22-7.mol |  |
| | ODZXEQVQLJKSQH-UHFFFAOYSA-N Chemical Properties |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Solid | | color | Light yellow to yellow |
| | ODZXEQVQLJKSQH-UHFFFAOYSA-N Usage And Synthesis |
| Uses | Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs[1]. | | IC 50 | Cereblon | | References | [1] Makbul C, Nassal M, Bttcher B. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14. DOI:10.7554/eLife.57277
[2] Sato T, Ito T, Handa H. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326 |
| | ODZXEQVQLJKSQH-UHFFFAOYSA-N Preparation Products And Raw materials |
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