|
|
| | 4-Amino-4'-chlorodiphenyl ether Basic information |
| | 4-Amino-4'-chlorodiphenyl ether Chemical Properties |
| Melting point | 99-103 °C | | Boiling point | 205 °C / 12mmHg | | density | 1.1764 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | 4.60±0.10(Predicted) | | form | powder to crystal | | color | White to Light yellow to Light orange | | Water Solubility | Insoluble in water. | | InChI | 1S/C12H10ClNO/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8H,14H2 | | InChIKey | YTISFYMPVILQRL-UHFFFAOYSA-N | | SMILES | Nc1ccc(Oc2ccc(Cl)cc2)cc1 | | CAS DataBase Reference | 101-79-1(CAS DataBase Reference) | | EPA Substance Registry System | Benzenamine, 4-(4-chlorophenoxy)- (101-79-1) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-40-43-41-37/38-22 | | Safety Statements | 26-36/37/39-36/37 | | WGK Germany | 3 | | RTECS | BX1770000 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29222990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| Provider | Language |
|
ALFA
| English |
| | 4-Amino-4'-chlorodiphenyl ether Usage And Synthesis |
| Chemical Properties | Dark powder | | Uses | It is used as an active pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of 4'-chloro-4-amino-diphenyl ether from 4'-chloro-4-nitro-diphenyl ether: general method: 1-substituted-4-nitrobenzene (9.3 mmol) and hydrazine hydrate (27.9 mmol) were dissolved in 20 mL of ethanol, and stirred for 10 min at 28-30°C. The reaction was carried out in aqueous suspension of Raney-Ni (0.02 g). An aqueous suspension of Raney-Ni (0.02 g, 4.41 mL) was added in three 10-min intervals. after 30 min, the reaction was allowed to plateau, and the temperature was raised to 50-60 °C to continue stirring for 6 h. The catalyst was removed by filtration. After completion of the reaction, the catalyst was removed by filtration. The solvent was removed by evaporation to give the target product 4'-chloro-4-amino-diphenyl ether. | | References | [1] Green Chemistry, 2017, vol. 19, # 14, p. 3400 - 3407
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 7, p. 1588 - 1592
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 11, p. 4811 - 4815
[4] Pharmazie, 1980, vol. 35, # 2, p. 78 - 80 |
| | 4-Amino-4'-chlorodiphenyl ether Preparation Products And Raw materials |
|