| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
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| | 1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Basic information |
| | 1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: 1mg/mL | | form | lyophilized solid | | color | white |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | 1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Usage And Synthesis |
| Uses | A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (Ki,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.
A cell-permeable, potent, selective, reversible inhibitor of cathepsin K (Ki,app = 9.7 nM). At higher concentrations also inhibits the activities of cathepsin L, cathepsin B, and papain (Ki,app = 120 nM, 5.1 mM, and 2.3 µM, respectively). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. | | Biological Activity | Cell permeable: yes', 'Primary Target
Cathepsin K', 'Product does not compete with ATP.', 'Reversible: yes', 'Target Ki: 9.7 nM against cathepsin K |
| | 1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Preparation Products And Raw materials |
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