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| | N-[(2,4-dichlorophenyl)methyl]-1-propylbenzimidazol-5-amine Basic information |
| Product Name: | N-[(2,4-dichlorophenyl)methyl]-1-propylbenzimidazol-5-amine | | Synonyms: | N-[(2,4-dichlorophenyl)methyl]-1-propylbenzimidazol-5-amine;C-215
(C215);C215.HCL;C-215;M. tuberculosis,C 215,C-215,inhibit,MmpL3,macrophages,glycerol,toxicity,Inhibitor,C215,Bacterial;1H-Benzimidazol-5-amine, N-[(2,4-dichlorophenyl)methyl]-1-propyl-;C-215, 10 mM in DMSO;N-(2,4-Dichlorobenzyl)-1-propyl-1H-benzo[D]imidazol-5-amine | | CAS: | 912780-51-9 | | MF: | C17H17Cl2N3 | | MW: | 334.24 | | EINECS: | | | Product Categories: | | | Mol File: | 912780-51-9.mol | ![N-[(2,4-dichlorophenyl)methyl]-1-propylbenzimidazol-5-amine Structure](CAS/20180601/GIF/912780-51-9.gif) |
| | N-[(2,4-dichlorophenyl)methyl]-1-propylbenzimidazol-5-amine Chemical Properties |
| Boiling point | 499.1±55.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | pka | 6.10±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | N-[(2,4-dichlorophenyl)methyl]-1-propylbenzimidazol-5-amine Usage And Synthesis |
| Uses | C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC90 of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages[1]. | | References | [1] Stanley SA, Grant SS, Kawate T, et al. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012;7(8):1377-1384. DOI:10.1021/cb300151m |
| | N-[(2,4-dichlorophenyl)methyl]-1-propylbenzimidazol-5-amine Preparation Products And Raw materials |
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