CYAYKKUWALRRPA-UHFFFAOYSA-N manufacturers
|
| | CYAYKKUWALRRPA-UHFFFAOYSA-N Basic information |
| Product Name: | CYAYKKUWALRRPA-UHFFFAOYSA-N | | Synonyms: | CYAYKKUWALRRPA-UHFFFAOYSA-N;Hexopyranosyl bromide, 2,3,4,6-tetraacetate;6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide;2,3,4,6 Tetra o acetyl alpha galactosylpyranosyl bromide,PROTAC Linkers,2,3,4,6Tetraoacetylalphagalactosylpyranosyl bromide,Inhibitor,inhibit | | CAS: | 529493-92-3 | | MF: | C14H19BrO9 | | MW: | 411.2 | | EINECS: | | | Product Categories: | | | Mol File: | 529493-92-3.mol |  |
| | CYAYKKUWALRRPA-UHFFFAOYSA-N Chemical Properties |
| | CYAYKKUWALRRPA-UHFFFAOYSA-N Usage And Synthesis |
| Uses | 2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Biological Activity | 2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | Alkyl-Chain | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | CYAYKKUWALRRPA-UHFFFAOYSA-N Preparation Products And Raw materials |
|