- Androstenedione
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2026-04-20
- CAS:63-05-8
- Min. Order:
- Purity: 0.99
- Supply Ability:
- 4-Androstenedione
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- $0.00 / 1KG
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2025-12-25
- CAS:63-05-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5000KG
- Androstenedione
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- $40.00 / 1kg
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2025-06-20
- CAS:63-05-8
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10 tons
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| | Androstenedione Chemical Properties |
| Melting point | 170-171 °C(lit.) | | alpha | D30 +199° (in chloroform) | | Boiling point | 368.77°C (rough estimate) | | density | 1.0655 (rough estimate) | | refractive index | 1.4709 (estimate) | | Fp | 2℃ | | storage temp. | Controlled Substance, -20°C Freezer | | solubility | Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Sparingly) | | form | Solid | | color | Dimorphous: Needles from acetone, or crystalsfrom hexane | | Water Solubility | 57.28mg/L(25 ºC) | | Merck | 13,643 | | Henry's Law Constant | 2.7×102 mol/(m3Pa) at 25℃, HSDB (2015) | | InChI | 1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 | | InChIKey | AEMFNILZOJDQLW-QAGGRKNESA-N | | SMILES | [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)C(=O)CC[C@@]24[H] | | CAS DataBase Reference | 63-05-8(CAS DataBase Reference) | | NIST Chemistry Reference | Androst-4-ene-3,17-dione(63-05-8) | | EPA Substance Registry System | 4-Androstenedione (63-05-8) |
| | Androstenedione Usage And Synthesis |
| Biological Metabolism | The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
| | Description | Androstenedione (CRM) (Item No. ISO60161) is a certified reference material categorized as an anabolic androgenic steroid. Androstenedione is a precursor of testosterone (Item Nos. ISO60154 | ISO00154 | 15645) and estrone . Androstenedione is regulated as a Schedule III compound in the United States. Androstenedione (CRM) (Item No. ISO60161) is provided as a DEA exempt preparation. This product is intended for research and forensic applications. | | Chemical Properties | White to Off-White Solid | | Uses | Testosterone precursor and metabolite with androgenic activity.
Controlled substance (anabolic sterid) | | Definition | ChEBI: A 3-oxo Delta4-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads. | | Safety Profile | An experimental teratogen. Otherexperimental reproductive effects. Questionablecarcinogen with experimental tumorigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes. | | Purification Methods | Crystallise the dione from hexane. It is soluble in *C6H6, CHCl3 and EtOH. It has max at 239nm. It is a precursor of estrone or testosterone and has androgenic activity. [Ruzicka & Wettstein Helv Chim Acta 18 980 1935, Beilstein 7 III 3636, 7 IV 2381.] | | Toxics Screening Level | The initial threshold screening level (ITSL) for androstenedione is 17 μg/m3 based on an annual averaging time. | | References | [1] F. CHEN. Partial agonist/antagonist properties of androstenedione and 4-androsten-3β,17β-diol[J]. Journal of Steroid Biochemistry and Molecular Biology, 2004, 91 4: Pages 247-257. DOI: 10.1016/j.jsbmb.2004.04.009
[2] Toxicology and carcinogenesis studies of androstenedione (CAS No. 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies).[J]. National Toxicology Program technical report series, 2010, 560: 1, 7-31,33-171 passim.
[3] OSTOJI S, CALLEJA-GONZáLEZ J, STOJANOVI M. Steroid Prohormones: Effects on Body Composition in Athletes[C]. 2011: 0. DOI: 10.5772/28543 |
| | Androstenedione Preparation Products And Raw materials |
| Raw materials | beta-Sitosterol-->3-keto-23,24-bisnorchol-4-en-22-ol-->CAMPESTEROL-->Cholesterol-->(8S,9R,10S,13S,14S,17S)-9,17-dihydroxy-10,13-dimethyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one | | Preparation Products | Spironolactone-->5B-ANDROSTANE-3,17-DIONE-->Androsta-1,4-diene-3,17-dione-->Testosterone undecanoate-->Androst-3-en-17-one,(5)-->5α-Androstane-3,6,17-trione-->11α-Hydroxyandrost-4-ene-317-dione-->Methyl 3-oxo-4-androstene-17beta-carboxylate-->6-Methyleneandrost-4-ene-3,17-dione |
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