3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide

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Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:MitoBloCK-10 CAS:394694-98-5 Purity:99.51% Package:1mg;64USD\|5mg;155USD\|10mg;228USD

Company Name:	InvivoChem
Tel:	+1-708-310-1919 +1-13798911105
Email:	sales@invivochem.cn
Products Intro:	Product Name:MB-10 CAS:394694-98-5 Purity:98% Package:1mg Remarks:V2243

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354;
Email:	support@targetmol.com
Products Intro:	Product Name:MitoBloCK-10；3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m CAS:394694-98-5 Package:1 mg；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Aladdin Scientific
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Email:	tp@aladdinsci.com
Products Intro:	Product Name:MitoBloCK-10 CAS:394694-98-5 Purity:98% Package:$50.9/500μg;$80.9/1mg;$200.9/5×1mg;Bulk package Remarks:98%

Company Name:	Nanjing Chemlin Chemical Co., Ltd
Tel:	025-83697070
Email:	info@chemlin.com.cn
Products Intro:	Product Name:MitoBloCK-10 CAS:394694-98-5

3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide manufacturers

3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide Basic information

Product Name:	3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide
Synonyms:	3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide;MitoBloCK-10 (MB-10);Benzoic acid, 3-fluoro-, 2-[(5-nitro-2-thienyl)methylene]hydrazide;3-Fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide;MB-10;3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m;Mitochondrial,Protein,Tim44,MitoBloCK10,MitoBloCK 10,MitoBloCK-10,inhibit,Inhibitor,Import;MitoBloCK-10, 10 mM in DMSO
CAS:	394694-98-5
MF:	C12H8FN3O3S
MW:	293.27
EINECS:
Product Categories:
Mol File:	394694-98-5.mol

3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide Chemical Properties

density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 2mg/mL, clear
pka	11.21±0.46(Predicted)
form	Solid
color	Light yellow to yellow
InChI	1S/C12H8FN3O3S/c13-9-3-1-2-8(6-9)12(17)15-14-7-10-4-5-11(20-10)16(18)19/h1-7H,(H,15,17)/b14-7+
InChIKey	QDYQZMWFIYLMNX-VGOFMYFVSA-N
SMILES	Fc1cc(ccc1)C(=O)N\N=C\c2[s]c(cc2)[N+](=O)[O-]

Safety Information

MSDS Information

3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide Usage And Synthesis

Uses	MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70[1].
Biological Activity	Mitochondrial import blocker of substances requiring inner membrane translocon TIM23. MitoBloCK-10 (MB-10) is mitochondrial import blocker of substances requiring inner membrane translocon TIM23 (TIM23) in yeast and mammalian mitochondria. It appears th at MB-10 targets Tim44 of the PAM complex. MitoBloCK-10 does not alter respiraton. MB-10 inhibits cardiac development and induces apoptosis in Zebrafish embryos. It inhibits bladder cancer cell growth in vitro and in vivo.
References	[1] Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442. DOI:10.1074/jbc.M116.770131

3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide Preparation Products And Raw materials

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