4-Hydroxy-D-(-)-2-phenylglycine

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Company Name:	Hebei Chuanghai Biotechnology Co., Ltd
Tel:	+8615350571055
Email:	Sibel@chuanghaibio.com
Products Intro:	Product Name:4-Hydroxy-D-(-)-2-phenylglycine CAS:22818-40-2 Purity:99% Package:1KG;10.00;USD

Company Name:	Hebei Chuanghai Biotechnology Co,.LTD
Tel:	+86-86-13131129325 +8613131129325
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Products Intro:	Product Name:D(-)-4-Hydroxyphenylglycine CAS:22818-40-2 Purity:99% Package:1kg;10.70;USD

Company Name:	Hebei Chuanghai Biotechnology Co., Ltd
Tel:	+8615531151365
Email:	mina@chuanghaibio.com
Products Intro:	Product Name:4-Hydroxy-D-(-)-2-phenylglycine CAS:22818-40-2 Purity:99% Package:1KG;0.00;USD\|25KG;0.00;USD\|1000KG;0.00;USD

Company Name:	Henan Bao Enluo International TradeCo.，LTD
Tel:	+86-17331933971
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Products Intro:	Product Name:4-Hydroxy-D-(-)-2-phenylglycine CAS:22818-40-2 Purity:99.99% Package:1kg;10USD

Company Name:	Apeloa production Co.,Limited
Tel:	+8619933239880
Email:	admin@apcl.com.cn
Products Intro:	Product Name:D(-)-4-Hydroxyphenylglycine CAS:22818-40-2 Purity:98% Package:1g;1.00;USD

4-Hydroxy-D-(-)-2-phenylglycine manufacturers

4-Hydroxy-D-(-)-2-phenylglycine Basic information

Product Name:	4-Hydroxy-D-(-)-2-phenylglycine
Synonyms:	4-HYDROXY-D-PHENYLGLYCINE;(R)-(-)-AMINO(4-HYDROXYPHENYL)ACETIC ACID;(R)-AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID;(r)-alpha-amino-4-hydroxybenzeneacetic acid;(R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID;(R)-4-HYDROXYPHENYLGLYCINE;(R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE;D-(-)-2-(4-HYDROXYPHENYL)GLYCINE
CAS:	22818-40-2
MF:	C8H9NO3
MW:	167.16
EINECS:	245-247-7
Product Categories:	Antidote / Antibiotic / Antimicrobial;Miscellaneous Biochemicals;Amino ACIDS SERIES;Cephalosporins;Peptide Synthesis;Phenylglycine Derivatives;Unnatural Amino Acid Derivatives;Pharmaceutical Intermediates;Odevixibat;22818-40-2
Mol File:	22818-40-2.mol

4-Hydroxy-D-(-)-2-phenylglycine Chemical Properties

Melting point	240 °C (dec.)(lit.)
alpha	-156 º (c=1, 1 N HCl)
Boiling point	295.73°C (rough estimate)
density	1.396
vapor pressure	0Pa at 25℃
refractive index	-158 ° (C=1, 1mol/L HCl)
storage temp.	2-8°C
solubility	5g/l
pka	2.15±0.10(Predicted)
form	Liquid
color	Clear colorless to yellow
Optical Rotation	[α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility	5 g/L (20 ºC)
BRN	2210998
Major Application	peptide synthesis
InChI	1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)/t7-/m1/s1
InChIKey	LJCWONGJFPCTTL-SSDOTTSWSA-N
SMILES	N[C@@H](C(O)=O)c1ccc(O)cc1
LogP	-2.25
CAS DataBase Reference	22818-40-2(CAS DataBase Reference)
EPA Substance Registry System	Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)

Safety Information

MSDS Information

Provider	Language
(R)-alpha-Amino-4-hydroxybenzeneacetic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

4-Hydroxy-D-(-)-2-phenylglycine Usage And Synthesis

Description	d-(p-Hydroxyphenyl)glycine (d-HPG) is widely used in large amounts as an important intermediate for the synthesis of amoxicillin and several other semisynthetic β-lactam antibiotics.
Chemical Properties	off-white powder
Uses	4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
Uses	4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
Definition	ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.
Flammability and Explosibility	Non flammable
reaction suitability	reaction type: solution phase peptide synthesis
Purification Methods	Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]

4-Hydroxy-D-(-)-2-phenylglycine Preparation Products And Raw materials

Raw materials	Phenol-->Glyoxal-->Glyoxylic acid-->p-Anisaldehyde-->D(-)-Tartaric acid-->DL-Tartaric acid-->DL-P-Hydroxyphenylglycine
Preparation Products	(2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-(4-hydroxyphenyl)acetic acid-->D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM-->(R)-3-BROMO-4-HYDROXYPHENYLGLYCINE-->Fmoc-D-4-Hydroxyphenylglycine-->(R)-AMINO-4-HYDROXY-CYCLOHEXANEACETIC ACID

Tag:4-Hydroxy-D-(-)-2-phenylglycine(22818-40-2) Related Product Information

4-Hydroxybenzoic acid 4-Aminophenylacetic acid Anilinoacetic acid D-2-Phenylglycine CHLOROPHOSPHONAZO III Methylparaben Betaine 4-Hydroxyphenylacetic acid 6-Aminocaproic acid D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM,D-(-)-ALPHA-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM L-Phenylglycine 4-Hydroxybenzaldehyde D-4-Hydroxyphenylglycine methyl ester D(+)-Trehalose dihydrate D(+)-Malic acid Glycine α-Lipoic Acid (S)-Amlodipine