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| | 1-Propanesulfonyl chloride Basic information |
| | 1-Propanesulfonyl chloride Chemical Properties |
| Melting point | -37 °C | | Boiling point | 78-79 °C/15 mmHg (lit.) | | density | 1.267 g/mL at 25 °C (lit.) | | vapor density | 4.9 (vs air) | | refractive index | n20/D 1.453(lit.) | | Fp | 176 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | clear liquid | | color | Colorless to Light yellow | | Water Solubility | Decomposes in hot water. | | Sensitive | Moisture Sensitive | | BRN | 1747500 | | InChI | 1S/C3H7ClO2S/c1-2-3-7(4,5)6/h2-3H2,1H3 | | InChIKey | KPBSJEBFALFJTO-UHFFFAOYSA-N | | SMILES | CCCS(Cl)(=O)=O | | CAS DataBase Reference | 10147-36-1(CAS DataBase Reference) | | NIST Chemistry Reference | 1-Propanesulfonyl chloride(10147-36-1) | | EPA Substance Registry System | 1-Propanesulfonyl chloride (10147-36-1) |
| Hazard Codes | C | | Risk Statements | 14-34-36-R36-R34-R14 | | Safety Statements | 26-36/37/39-45-S45-S36/37/39-S26 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | F | 10-19-21 | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29049090 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Eye Irrit. 2
Skin Corr. 1B |
| | 1-Propanesulfonyl chloride Usage And Synthesis |
| Description | 1-Propanesulfonyl chloride is a highly reactive sulfonyl chloride derivative that is highly hygroscopic. It is primarily used as a pharmaceutical intermediate or an organic synthesis reagent in the preparation of sulfonamide drugs, such as abrocitinib and vemurafenib. | | Chemical Properties | Light yellow liquid | | Uses | 1-Propanesulfonyl chloride was used in synthesis of 1-alkyl-3-methylimidazolium alkanesulfonate ionic liquids. | | Safety | 1-Propanesulfonyl chloride is corrosive and irritating. Contact may cause severe skin burns and eye damage. Safety goggles and gloves must be worn when handling this substance. | | Synthesis |
2,4,6-Trichloro-[1,3,5]-triazine (TCT) was added at room temperature to a solution of propane-1-sulfonic acid in acetone dry, followed by NEt3 dropwise. The resulting mixture was irradiated to 80 °C (50 W of MW power) for 20 min in a sealed tube (10 mL pressure-rated reaction vial) in a self-tuning single-mode irradiating synthesizer. The mixture was cooled rapidly to room temperature by passing compressed air through the microwave cavity for 1 min. After cooling to room temperature, the precipitate was filtered off on Celite to afford 1-Propanesulfonyl chloride[1].
| | References | [1] Lidia De Luca, Giampaolo Giacomelli. “An Easy Microwave-Assisted Synthesis of Sulfonamides Directly from Sulfonic Acids.” The Journal of Organic Chemistry 73 10 (2008): 3967–3969. |
| | 1-Propanesulfonyl chloride Preparation Products And Raw materials |
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