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| | 2-Amino-4-(trifluoromethyl)pyrimidine Basic information |
| | 2-Amino-4-(trifluoromethyl)pyrimidine Chemical Properties |
| Melting point | 175-177°C | | Boiling point | 260.7±50.0 °C(Predicted) | | density | 1.460±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 1.90±0.10(Predicted) | | color | White to Light yellow | | λmax | 308nm(EtOH aq.)(lit.) | | InChI | 1S/C5H4F3N3/c6-5(7,8)3-1-2-10-4(9)11-3/h1-2H,(H2,9,10,11) | | InChIKey | NKOTXYPTXKUCDL-UHFFFAOYSA-N | | SMILES | Nc1nccc(n1)C(F)(F)F | | CAS DataBase Reference | 16075-42-6(CAS DataBase Reference) |
| Hazard Codes | Xi,N,T | | Risk Statements | 36/37/38-50-43-36-25 | | Safety Statements | 26-36/37/39-61-45-36/37 | | RIDADR | 2811 | | WGK Germany | 3 | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 29335990 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Oral
Aquatic Acute 1
Eye Irrit. 2
Resp. Sens. 1 |
| Provider | Language |
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ALFA
| English |
| | 2-Amino-4-(trifluoromethyl)pyrimidine Usage And Synthesis |
| Chemical Properties | White to brown powder | | Synthesis | Step 2: To a solution of compound [63] (22.8 g, 2.4 mmol, 1 eq.) in anhydrous ethanol (100 mL), NaOH granules (9.55 g, 238 mmol, 1 eq.) were added and the reaction mixture was stirred for 16 h at room temperature. Subsequently, a solution of compound [84] was slowly added through a dropping funnel over a period of 2 hours. After addition, the reaction mixture was continued to be stirred for 2 hours. Upon completion of the reaction, the solvent was removed by evaporation and the residue was dissolved in water (500 mL) with vigorous stirring for 2 hours, followed by standing at room temperature overnight. The precipitate precipitated was collected by filtration and dried under vacuum to give compound [85] as a light yellow solid (20.6 g, 53% yield). | | References | [1] Patent: WO2014/16849, 2014, A2. Location in patent: Page/Page column 117 |
| | 2-Amino-4-(trifluoromethyl)pyrimidine Preparation Products And Raw materials |
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