- 5-Nitropyridin-2-ol
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- $6.00 / 1KG
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2025-09-25
- CAS:5418-51-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 2-Hydroxy-5-nitropyridine Basic information |
| | 2-Hydroxy-5-nitropyridine Chemical Properties |
| Melting point | 188-191 °C (lit.) | | Boiling point | 256.56°C (rough estimate) | | density | 1.5657 (rough estimate) | | refractive index | 1.4800 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Very Slightly) | | pka | 8.06±0.10(Predicted) | | form | Crystalline Powder | | color | Light yellow to beige | | Water Solubility | Soluble in hot water and alkali liquor, Insoluble in most of organic solvents. | | BRN | 120352 | | InChI | InChI=1S/C5H4N2O3/c8-5-2-1-4(3-6-5)7(9)10/h1-3H,(H,6,8) | | InChIKey | XKWSQIMYNVLGBO-UHFFFAOYSA-N | | SMILES | C1(=O)NC=C([N+]([O-])=O)C=C1 | | CAS DataBase Reference | 5418-51-9(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Hydroxy-5-nitropyridine(5418-51-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Hydroxy-5-nitropyridine Usage And Synthesis |
| Chemical Properties | light yellow to beige crystalline powder | | Uses | A comparison of catalysts promotes imidazolide couplings including the identification of 2-hydroxy-5-nitropyridine as a new, safe, and effective catalyst. | | Synthesis | General procedure for the synthesis of 2-hydroxy-5-nitropyridine from 2-amino-5-nitropyridine: 2-amino-5-nitropyridine (13.9 g, 0.1 mol) was dissolved in 55.6 g of 15% dilute hydrochloric acid, and 44.85 g of 20% aqueous sodium nitrite (NaNO2) was added slowly dropwise. After the dropwise addition, the reaction was continued for 6 hours. The reaction temperature was maintained at 40°C for 40 minutes. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and a light yellow solid was precipitated after cooling. The solid was washed with ice water and dried to obtain 2-hydroxy-5-nitropyridine (12.61 g), which was analyzed by high performance liquid chromatography (HPLC) with a purity of 97.69% and a yield of 88.02%. | | References | [1] Patent: CN105523995, 2016, A. Location in patent: Paragraph 0026; 0047; 0048
[2] Chemistry of Heterocyclic Compounds, 2002, vol. 38, # 7, p. 805 - 809
[3] Bulletin of the Chemical Society of Japan, 1987, vol. 60, # 10, p. 3597 - 3602
[4] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1914, vol. 46, p. 1240
[5] Chem. Zentralbl., 1915, vol. 86, # I, p. 1066 |
| | 2-Hydroxy-5-nitropyridine Preparation Products And Raw materials |
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