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| | (S)-1-(3-Trifluoromethylphenyl)-2-aminopropane Basic information |
| Product Name: | (S)-1-(3-Trifluoromethylphenyl)-2-aminopropane | | Synonyms: | (S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-PROPANAMINE;(S)-α-Methyl-3-(trifluoromethyl)benzeneethanamine;[S,(+)]-α-Methyl-3-(trifluoromethyl)benzeneethanamine;[S,(+)]-α-Methyl-m-(trifluoromethyl)phenethylamine;Dexnorfenfluramine;Nordexfenfluramine;Einecs 242-769-7;S-Norfenfluramine | | CAS: | 19036-73-8 | | MF: | C10H12F3N | | MW: | 203.2 | | EINECS: | 2427697 | | Product Categories: | | | Mol File: | 19036-73-8.mol |  |
| | (S)-1-(3-Trifluoromethylphenyl)-2-aminopropane Chemical Properties |
| storage temp. | 4°C, protect from light | | form | Liquid | | color | Colorless to light yellow |
| | (S)-1-(3-Trifluoromethylphenyl)-2-aminopropane Usage And Synthesis |
| Uses | (+)-Norfenfluramine a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). (+)-Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+)-Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease[1]. | | Definition | ChEBI: (2S)-1-[3-(trifluoromethyl)phenyl]-2-propanamine is a member of amphetamines. | | in vivo | (+)-Norfenfluramine (1-300 μg/kg, i.v.) induces pressor response in conscious SHAM and DOCA-salt rats[1].
(+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats[3].
| Animal Model: | Conscious SHAM and DOCA-salt rats[1].
| | Dosage: | 1-300 μg/kg | | Administration: | Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals. | | Result: | Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19).
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| | IC 50 | 5-HT2B Receptor: 11.2 nM (Ki); 5-HT2A Receptor: 1516 nM (Ki); 5-HT2C Receptor: 324 nM (Ki) | | References | [1] Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. DOI:10.1124/jpet.106.114017
[2] M Gobbi, et al. In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):323-7. DOI:10.1007/pl00005260
[3] R Invernizzi, et al. Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain Br J Pharmacol. 1982 Mar;75(3):525-30. DOI:10.1111/j.1476-5381.1982.tb09169.x |
| | (S)-1-(3-Trifluoromethylphenyl)-2-aminopropane Preparation Products And Raw materials |
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