1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-triphosphate, (Na+ salt)

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1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-triphosphate, (Na+ salt) Basic information
Product Name:1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-triphosphate, (Na+ salt)
Synonyms:1-(1-OCTADECANOYL-2R-(5Z,8Z,11Z,14Z)-EICOSATETRAENOYLPHOSPHATIDYL)INOSITOL-3,4,5-TRIPHOSPHATE, HEPTASODIUM SALT;C-20:4;PHOSPHATIDYLINOSITOL-3,4,5-TRIPHOSPHATE C-18 SODIUM SALT;PTDINS-(3,4,5)-P3 (1-STEAROYL, 2-ARACHIDONOYL) SODIUM SALT;SAPI-3,4,5-P3 (NA+ SALT);1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-triphosphate, (Na+ salt)
CAS:
MF:C47H79Na7O22P4
MW:1280.94
EINECS:
Product Categories:
Mol File:Mol File
1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-triphosphate, (Na+ salt) Structure
1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-triphosphate, (Na+ salt) Chemical Properties
solubility CHCl3:CH3OH:H2O (3:2:1): 10 mg/mlPBS (pH 7.2): Freely soluble
Safety Information
MSDS Information
1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-triphosphate, (Na+ salt) Usage And Synthesis
DescriptionPtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins.1,2 Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references 3 and 4.WARNING This product is not for human or veterinary use.
References[1] KENICHI TANAKA. A Target of Phosphatidylinositol 3,4,5-Trisphosphate with a Zinc Finger Motif Similar to that of the ADP-Ribosylation-Factor GTPase-Activating Protein and Two Pleckstrin Homology Domains[J]. The FEBS journal, 2004, 245 2: 512-519. DOI: 10.1111/j.1432-1033.1997.00512.x
[2] X YANG. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate.[J]. The Journal of Biological Chemistry, 1999, 274 27: 18973-18980. DOI: 10.1074/jbc.274.27.18973
[3] L J PIKE  L C. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains.[J]. The Journal of Biological Chemistry, 1996, 271 43: 26453-26456. DOI: 10.1074/jbc.271.43.26453
[4] BERRIDGE M J. Inositol trisphosphate and calcium signalling[J]. Nature, 1993, 361 6410: 315-325. DOI: 10.1038/361315a0
1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-triphosphate, (Na+ salt) Preparation Products And Raw materials
Tag:1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-triphosphate, (Na+ salt) Related Product Information
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