| Company Name: |
Twochem Co.Ltd. |
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021-58111628 15800915896 |
| Email: |
sales@twochem.com |
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| | BMS-852927 Basic information |
| Product Name: | BMS-852927 | | Synonyms: | BMS-852927;2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3'-difluoro-4'-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol;BMS-852927
(BMS 852927;XL-041);1H-Imidazole-4-methanol, 2-[1-(2,6-dichlorophenyl)-1-methylethyl]-1-[3,3'-difluoro-4'-(hydroxymethyl)-5'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-α,α-dimethyl-;XL041（BMS-852927）;XL041,XL-041;XL041 | | CAS: | 1256918-39-4 | | MF: | C29H28Cl2F2N2O4S | | MW: | 609.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1256918-39-4.mol |  |
| | BMS-852927 Chemical Properties |
| Boiling point | 810.6±75.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 150 mg/mL (246.10 mM) | | form | Solid | | pka | 11.20±0.10(Predicted) | | color | White to off-white |
| | BMS-852927 Usage And Synthesis |
| Uses | XL041 (BMS-852927) is an LXRβ-selective agonist. | | in vivo | XL041 (BMS-852927), has a very favorable profile at efficacious doses in cynomolgus monkeys and mice. XL041 pre-treatment of C57BL/6J mice for 7 days results in potent, dose-dependent stimulation of cholesterol efflux in this system, reaching a maximum in the 3 mg/kg/day dose group of 70% above vehicle in the initial efflux rate. Similar results are obtained in LDLR knockout (KO) mice. In a separate study, XL041 inhibits the progression of atherosclerosis in a 12 week study in LDLR KO mice. Importantly, the dose response for inhibition of atherosclerosis (0.1-3 mg/kg/day) is similar to the dose response for macrophage reverse cholesterol transport (RCT) stimulation (0.03-3 mg/kg/day), a major underlying mechanism through which LXR agonists affect the disease[1]. | | References | [1] Kirchgessner TG, et al. Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils. Cell Metab. 2016 Aug 9;24(2):223-33. DOI:10.1016/j.cmet.2016.07.016 |
| | BMS-852927 Preparation Products And Raw materials |
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