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| | 5-CYANO-3-PYRIDINYL BORONIC ACID Basic information |
| Product Name: | 5-CYANO-3-PYRIDINYL BORONIC ACID | | Synonyms: | Boronic acid, (5-cyano-3-pyridinyl)- (9CI);Boronic acid, B-(5-cyano-3-pyridinyl)-;REF DUPL: 5-Cyanopyridine-3-boronic acid;3-Cyanopyridine-5-boronic acid, 3-Borono-5-cyanopyridine;3-Cyanopyridine-5-boronic acid;5-Cyano-3-pyridineboronic acid;B-(5-cyano-3-pyridinyl)-Boronic acid;5-cyanopyridin-3-boronic acid | | CAS: | 497147-93-0 | | MF: | C6H5BN2O2 | | MW: | 147.93 | | EINECS: | | | Product Categories: | PYRIDINE | | Mol File: | 497147-93-0.mol |  |
| | 5-CYANO-3-PYRIDINYL BORONIC ACID Chemical Properties |
| Boiling point | 375.9±52.0 °C(Predicted) | | density | 1.34 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | Crystalline Powder | | pka | 5.52±0.10(Predicted) | | color | White to yellow | | InChI | 1S/C6H5BN2O2/c8-2-5-1-6(7(10)11)4-9-3-5/h1,3-4,10-11H | | InChIKey | CYEXXDYQJPRMIQ-UHFFFAOYSA-N | | SMILES | OB(O)c1cncc(c1)C#N |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-39 | | WGK Germany | WGK 3 | | HS Code | 29333999 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 5-CYANO-3-PYRIDINYL BORONIC ACID Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-cyano-3-pyridinylboronic acid from 3-cyano-5-bromopyridine and pinacol ester of biphenylboronic acid: to a 500-mL two-necked flask were added 3-bromo-5-cyanopyridine (0.63 g, 2.5 mmol), 1,1-bis(diphenylphosphino)ferrocene palladium dichloride (0.17 g, 0.21 mmol), and potassium aminoglycolate (0.61 g, 6.21 mmol). The mixture was dissolved in 6 mL of 1,4-dioxane, heated to 90 °C and stirred for 21 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered through diatomaceous earth. The filtrate was distilled under reduced pressure and dried to give 0.1 g of the target product 5-cyano-3-pyridinylboronic acid (yield: 32%). | | References | [1] Patent: KR2017/79357, 2017, A. Location in patent: Paragraph 0300-0303
[2] Patent: WO2012/3283, 2012, A1. Location in patent: Page/Page column 187 |
| | 5-CYANO-3-PYRIDINYL BORONIC ACID Preparation Products And Raw materials |
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