| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
|
| | N-Acetyl-DL-2-amino-n-butyric acid Basic information |
| Product Name: | N-Acetyl-DL-2-amino-n-butyric acid | | Synonyms: | AC-DL-ALPHA-AMINOBUTYRIC ACID;AC-DL-ABU-OH;AC-DL-2-AMINOBUTANOIC ACID;AC-DL-2-ABU-OH;ACETYL-DL-BUTYRIN;2-ACETAMIDO-N-BUTYRIC ACID;N-ALPHA-ACETYL-DL-2-AMINOBUTYRIC ACID;N-ACETYL-DL-2-AMINO-BUTYRIC ACID | | CAS: | 7211-57-6 | | MF: | C6H11NO3 | | MW: | 145.16 | | EINECS: | | | Product Categories: | | | Mol File: | 7211-57-6.mol |  |
| | N-Acetyl-DL-2-amino-n-butyric acid Chemical Properties |
| Melting point | 132 °C | | Boiling point | 368.2±25.0 °C(Predicted) | | density | 1.129 | | storage temp. | Sealed in dry,Room Temperature | | Water Solubility | Slightly soluble in water | | solubility | soluble in Acetone, Water | | form | powder to crystal | | pka | 3.68±0.10(Predicted) | | color | White to Almost white |
| | N-Acetyl-DL-2-amino-n-butyric acid Usage And Synthesis |
| Uses | 2-(Acetylamino)butanoic Acid-d5 is an intermediate of Isotope labelled L-2-Aminobutyric Acid (A602930) Receptor antagonist. | | Synthesis Reference(s) | Tetrahedron Letters, 28, p. 2829, 1987 DOI: 10.1016/S0040-4039(00)96220-8 | | Synthesis | General procedure for the synthesis of 2-acetylaminobutyric acid from ethanoic anhydride and DL-2-aminobutyric acid:
1. dissolve 163 g (1.58 mol) of DL-2-aminobutyric acid in an appropriate amount of acetic acid.
2. 242 g (2.37 mol) of acetic anhydride was added slowly and dropwise to the above solution.
3. the reaction mixture was stirred continuously at 100 °C for 2 hours until the reaction was complete.
4. After completion of the reaction, the solvent was removed by vacuum evaporation to give a solid residue.
5. The solid residue was suspended in ethyl acetate and filtered.
6. The filter cake was washed with ether to remove unreacted raw materials and by-products.
7. The target product 2-acetylaminobutyric acid was obtained after drying in a yield of 220 g (95.9% yield).
Product characterization data: 1H-NMR (methanol-d4) δ/ppm 0.97 (t, 3H), 1.65-1.93 (m, 2H), 1.99 (s, 3H), 4.29 (q, 1H). | | References | [1] Patent: WO2003/93268, 2003, A1. Location in patent: Page/Page column 25
[2] Patent: WO2003/93270, 2003, A1. Location in patent: Page/Page column 21
[3] Patent: WO2003/97645, 2003, A1. Location in patent: Page/Page column 26
[4] Biochemical Journal, 1939, vol. 33, p. 1915
[5] Journal of Physical Chemistry, 1984, vol. 88, # 1, p. 86 - 92 |
| | N-Acetyl-DL-2-amino-n-butyric acid Preparation Products And Raw materials |
|