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| | 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YLAMINE Basic information | | Uses |
| Product Name: | 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YLAMINE | | Synonyms: | 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YLAMINE;3-Amino-5-bromo-1H-pyrazolo[3,4-B]pyridine;3-Amino-5-bromo-1H-pyrazo...;5-Bromo-1H-pyrazolo[3,4-b]pyridin-3-amine, 3-Amino-7-aza-5-bromo-1H-indazole;1H-Pyrazolo[3,4-b]pyridin-3-aMine,5-broMo-;5-Bromo-1H-pyrazole[3,4-b]pyridin-3-amine;5-bromo-1H-pyrazolo[3,4-b]pyridine-3-amine;5-Bromo-1H-pyrazolo[3,4-b]pyridin-ylamine | | CAS: | 405224-24-0 | | MF: | C6H5BrN4 | | MW: | 213.03 | | EINECS: | | | Product Categories: | | | Mol File: | 405224-24-0.mol | ![5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YLAMINE Structure](CAS/GIF/405224-24-0.gif) |
| | 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YLAMINE Chemical Properties |
| Boiling point | 429.1±40.0 °C(Predicted) | | density | 1.994 | | storage temp. | 2-8°C(protect from light) | | pka | 9.55±0.40(Predicted) | | form | solid | | Appearance | Light yellow to yellow Solid | | InChI | InChI=1S/C6H5BrN4/c7-3-1-4-5(8)10-11-6(4)9-2-3/h1-2H,(H3,8,9,10,11) | | InChIKey | SSNUTEUZXZIYTB-UHFFFAOYSA-N | | SMILES | C12NN=C(N)C1=CC(Br)=CN=2 |
| Hazard Codes | Xn | | Risk Statements | 22 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YLAMINE Usage And Synthesis |
| Uses | 3-Amino-5-bromo-1H-pyrazolo[3,4-B]pyridine is an organic intermediate. | | Synthesis | General procedure for the synthesis of 3-amino-5-bromo-1H-pyrazolo[3,4-b]pyridine from 5-bromo-2-chloronicotinonitrile: Compound 3 (5-bromo-2-chloronicotinonitrile, 307 mg, 1.4 mmol) was dissolved in ethanol (10 mL) in a microwave reactor tube, followed by the addition of 5 equiv. of hydrazine hydrate (NH2NH2-H2O) to the solution. The reaction mixture was placed in a microwave reactor and radiated at 170 °C for 10 min. Upon completion of the reaction, the solvent was removed by rotary evaporator to afford the target product 3-amino-5-bromo-1H-pyrazolo[3,4-b]pyridine (4) in quantitative yield. | | References | [1] Patent: WO2007/59219, 2007, A1. Location in patent: Page/Page column 54-55
[2] Patent: WO2016/26549, 2016, A1. Location in patent: Page/Page column 43
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 20, p. 5578 - 5585
[4] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 9, p. 1577 - 1580
[5] Patent: WO2013/42035, 2013, A1. Location in patent: Page/Page column 17 |
| | 5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YLAMINE Preparation Products And Raw materials |
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